TY - JOUR
T1 - Greater secretion of growth hormone in black than in white men
T2 - Possible factor in greater bone mineral density - A Clinical Research Center Study
AU - Wright, Nancy M.
AU - Renault, Josette
AU - Willi, Steven
AU - Veldhuis, Johannes D.
AU - Pandey, Janardan P.
AU - Gordon, Leonie
AU - Key, L. Lyndon
AU - Bell, Norman H.
PY - 1995/8
Y1 - 1995/8
N2 - To determine why blacks have a higher bone mineral density (BMD) and lower incidence of osteoporosis and fractures than whites, we investigated whether the secretion of GH is higher in black than in white men. Measurements of GH were obtained at 20-min intervals over 24 h and analyzed by deconvolution. BMD was determined by dual energy x-ray absorptiometry in 16 normal black and 17 normal white men, aged 20-40 yr. The 24-h integrated GH concentration (942 ± 174 vs. 602 ± 104 μg/L; P = 0.0495) and GH secretory burst amplitude (0.499 ± 0.163 vs. 0.169 ± 0.027 μg/L · min; P = 0.0482) were higher in black than in white men. GH burst frequency, half-duration, mass, and half- life were not different in the 2 groups. The serum 17β-estradiol level (162 ± 12 vs. 108 ± 11 pmol/L; P = 0.0011) was higher, and the serum insulin- like growth factor-binding protein 3 level (2.2 ± 0.1 vs. 2.8 ± 0.1 μg/mL; P = 0.0001) was lower in black than in white men. BMD values for total body (1.22 ± 0.02 vs. 1.14 ± 0.02 g/cm2; P = 0.0041), forearm (0.69 ± 0.01 vs. 0.66 ± 0.01 g/cm2; P = 0.0211), trochanter (0.91 ± 0.03 vs. 0.77 ± 0.03 g/cm2; P = 0.0003), and femoral neck (1.08 ± 0.03 vs. 0.93 ± 0.03 g/cm2; P = 0.0007) were higher in black than in white men. Thus, serum 17β- estradiol level, GH secretion, and BMD values for the total body, forearm, trochanter, and femoral neck are greater in black than in white men. As estrogen is known to increase GH secretion and GH to increase bone mass, increases in circulating 17β-estradiol may contribute to the higher GH secretion and bone mass in black men.
AB - To determine why blacks have a higher bone mineral density (BMD) and lower incidence of osteoporosis and fractures than whites, we investigated whether the secretion of GH is higher in black than in white men. Measurements of GH were obtained at 20-min intervals over 24 h and analyzed by deconvolution. BMD was determined by dual energy x-ray absorptiometry in 16 normal black and 17 normal white men, aged 20-40 yr. The 24-h integrated GH concentration (942 ± 174 vs. 602 ± 104 μg/L; P = 0.0495) and GH secretory burst amplitude (0.499 ± 0.163 vs. 0.169 ± 0.027 μg/L · min; P = 0.0482) were higher in black than in white men. GH burst frequency, half-duration, mass, and half- life were not different in the 2 groups. The serum 17β-estradiol level (162 ± 12 vs. 108 ± 11 pmol/L; P = 0.0011) was higher, and the serum insulin- like growth factor-binding protein 3 level (2.2 ± 0.1 vs. 2.8 ± 0.1 μg/mL; P = 0.0001) was lower in black than in white men. BMD values for total body (1.22 ± 0.02 vs. 1.14 ± 0.02 g/cm2; P = 0.0041), forearm (0.69 ± 0.01 vs. 0.66 ± 0.01 g/cm2; P = 0.0211), trochanter (0.91 ± 0.03 vs. 0.77 ± 0.03 g/cm2; P = 0.0003), and femoral neck (1.08 ± 0.03 vs. 0.93 ± 0.03 g/cm2; P = 0.0007) were higher in black than in white men. Thus, serum 17β- estradiol level, GH secretion, and BMD values for the total body, forearm, trochanter, and femoral neck are greater in black than in white men. As estrogen is known to increase GH secretion and GH to increase bone mass, increases in circulating 17β-estradiol may contribute to the higher GH secretion and bone mass in black men.
UR - http://www.scopus.com/inward/record.url?scp=0029085899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029085899&partnerID=8YFLogxK
U2 - 10.1210/jc.80.8.2291
DO - 10.1210/jc.80.8.2291
M3 - Article
C2 - 7543111
AN - SCOPUS:0029085899
SN - 0021-972X
VL - 80
SP - 2291
EP - 2297
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 8
ER -