Greater secretion of growth hormone in black than in white men

Possible factor in greater bone mineral density - A Clinical Research Center Study

Nancy M. Wright, Josette Renault, Steven Willi, Johannes D Veldhuis, Janardan P. Pandey, Leonie Gordon, L. Lyndon Key, Norman H. Bell

Research output: Contribution to journalArticle

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Abstract

To determine why blacks have a higher bone mineral density (BMD) and lower incidence of osteoporosis and fractures than whites, we investigated whether the secretion of GH is higher in black than in white men. Measurements of GH were obtained at 20-min intervals over 24 h and analyzed by deconvolution. BMD was determined by dual energy x-ray absorptiometry in 16 normal black and 17 normal white men, aged 20-40 yr. The 24-h integrated GH concentration (942 ± 174 vs. 602 ± 104 μg/L; P = 0.0495) and GH secretory burst amplitude (0.499 ± 0.163 vs. 0.169 ± 0.027 μg/L · min; P = 0.0482) were higher in black than in white men. GH burst frequency, half-duration, mass, and half- life were not different in the 2 groups. The serum 17β-estradiol level (162 ± 12 vs. 108 ± 11 pmol/L; P = 0.0011) was higher, and the serum insulin- like growth factor-binding protein 3 level (2.2 ± 0.1 vs. 2.8 ± 0.1 μg/mL; P = 0.0001) was lower in black than in white men. BMD values for total body (1.22 ± 0.02 vs. 1.14 ± 0.02 g/cm2; P = 0.0041), forearm (0.69 ± 0.01 vs. 0.66 ± 0.01 g/cm2; P = 0.0211), trochanter (0.91 ± 0.03 vs. 0.77 ± 0.03 g/cm2; P = 0.0003), and femoral neck (1.08 ± 0.03 vs. 0.93 ± 0.03 g/cm2; P = 0.0007) were higher in black than in white men. Thus, serum 17β- estradiol level, GH secretion, and BMD values for the total body, forearm, trochanter, and femoral neck are greater in black than in white men. As estrogen is known to increase GH secretion and GH to increase bone mass, increases in circulating 17β-estradiol may contribute to the higher GH secretion and bone mass in black men.

Original languageEnglish (US)
Pages (from-to)2291-2297
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume80
Issue number8
DOIs
StatePublished - Aug 1995
Externally publishedYes

Fingerprint

Bone Density
Growth Hormone
Minerals
Bone
Research
Estradiol
Femur Neck
Forearm
Femur
Serum
Insulin-Like Growth Factor Binding Protein 3
Bone and Bones
Deconvolution
hydroquinone
Estrogens
Osteoporosis
Half-Life
X rays
X-Rays
Incidence

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Greater secretion of growth hormone in black than in white men : Possible factor in greater bone mineral density - A Clinical Research Center Study. / Wright, Nancy M.; Renault, Josette; Willi, Steven; Veldhuis, Johannes D; Pandey, Janardan P.; Gordon, Leonie; Key, L. Lyndon; Bell, Norman H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 80, No. 8, 08.1995, p. 2291-2297.

Research output: Contribution to journalArticle

Wright, Nancy M. ; Renault, Josette ; Willi, Steven ; Veldhuis, Johannes D ; Pandey, Janardan P. ; Gordon, Leonie ; Key, L. Lyndon ; Bell, Norman H. / Greater secretion of growth hormone in black than in white men : Possible factor in greater bone mineral density - A Clinical Research Center Study. In: Journal of Clinical Endocrinology and Metabolism. 1995 ; Vol. 80, No. 8. pp. 2291-2297.
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abstract = "To determine why blacks have a higher bone mineral density (BMD) and lower incidence of osteoporosis and fractures than whites, we investigated whether the secretion of GH is higher in black than in white men. Measurements of GH were obtained at 20-min intervals over 24 h and analyzed by deconvolution. BMD was determined by dual energy x-ray absorptiometry in 16 normal black and 17 normal white men, aged 20-40 yr. The 24-h integrated GH concentration (942 ± 174 vs. 602 ± 104 μg/L; P = 0.0495) and GH secretory burst amplitude (0.499 ± 0.163 vs. 0.169 ± 0.027 μg/L · min; P = 0.0482) were higher in black than in white men. GH burst frequency, half-duration, mass, and half- life were not different in the 2 groups. The serum 17β-estradiol level (162 ± 12 vs. 108 ± 11 pmol/L; P = 0.0011) was higher, and the serum insulin- like growth factor-binding protein 3 level (2.2 ± 0.1 vs. 2.8 ± 0.1 μg/mL; P = 0.0001) was lower in black than in white men. BMD values for total body (1.22 ± 0.02 vs. 1.14 ± 0.02 g/cm2; P = 0.0041), forearm (0.69 ± 0.01 vs. 0.66 ± 0.01 g/cm2; P = 0.0211), trochanter (0.91 ± 0.03 vs. 0.77 ± 0.03 g/cm2; P = 0.0003), and femoral neck (1.08 ± 0.03 vs. 0.93 ± 0.03 g/cm2; P = 0.0007) were higher in black than in white men. Thus, serum 17β- estradiol level, GH secretion, and BMD values for the total body, forearm, trochanter, and femoral neck are greater in black than in white men. As estrogen is known to increase GH secretion and GH to increase bone mass, increases in circulating 17β-estradiol may contribute to the higher GH secretion and bone mass in black men.",
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AU - Veldhuis, Johannes D

AU - Pandey, Janardan P.

AU - Gordon, Leonie

AU - Key, L. Lyndon

AU - Bell, Norman H.

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AB - To determine why blacks have a higher bone mineral density (BMD) and lower incidence of osteoporosis and fractures than whites, we investigated whether the secretion of GH is higher in black than in white men. Measurements of GH were obtained at 20-min intervals over 24 h and analyzed by deconvolution. BMD was determined by dual energy x-ray absorptiometry in 16 normal black and 17 normal white men, aged 20-40 yr. The 24-h integrated GH concentration (942 ± 174 vs. 602 ± 104 μg/L; P = 0.0495) and GH secretory burst amplitude (0.499 ± 0.163 vs. 0.169 ± 0.027 μg/L · min; P = 0.0482) were higher in black than in white men. GH burst frequency, half-duration, mass, and half- life were not different in the 2 groups. The serum 17β-estradiol level (162 ± 12 vs. 108 ± 11 pmol/L; P = 0.0011) was higher, and the serum insulin- like growth factor-binding protein 3 level (2.2 ± 0.1 vs. 2.8 ± 0.1 μg/mL; P = 0.0001) was lower in black than in white men. BMD values for total body (1.22 ± 0.02 vs. 1.14 ± 0.02 g/cm2; P = 0.0041), forearm (0.69 ± 0.01 vs. 0.66 ± 0.01 g/cm2; P = 0.0211), trochanter (0.91 ± 0.03 vs. 0.77 ± 0.03 g/cm2; P = 0.0003), and femoral neck (1.08 ± 0.03 vs. 0.93 ± 0.03 g/cm2; P = 0.0007) were higher in black than in white men. Thus, serum 17β- estradiol level, GH secretion, and BMD values for the total body, forearm, trochanter, and femoral neck are greater in black than in white men. As estrogen is known to increase GH secretion and GH to increase bone mass, increases in circulating 17β-estradiol may contribute to the higher GH secretion and bone mass in black men.

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