Gray matter involvement in multiple sclerosis

Istvan Pirko, Claudia F. Lucchinetti, Subramaniam Sriram, Rohit Bakshi

Research output: Contribution to journalReview article

268 Scopus citations

Abstract

Gray matter (GM) involvement is detected even in the earliest stages of multiple sclerosis (MS), and GM atrophy occurs at a faster rate than white matter (WM) atrophy early in the disease course. Studies published to date establish that 1) GM involvement and in particular cortical demyelination can be extensive in MS; 2) GM pathology may occur in part independently of WM lesion formation; 3) a primarily GM-related process may be the earliest manifestation of MS; 4) GM involvement is associated with physical disability, fatigue, and cognitive impairment in MS; and 5) GM disease might help explain the observed dissociation between markers of inflammatory demyelination (relapses, WM gadolinium enhancement, WM lesion burden) and disease progression. It remains likely that GM damage is related to WM damage. However, continued studies of GM pathology as well as neuronal and axonal involvement in MS and related experimental models are necessary to better understand the etiology and pathogenesis of the degenerative components.

Original languageEnglish (US)
Pages (from-to)634-642
Number of pages9
JournalNeurology
Volume68
Issue number9
DOIs
StatePublished - Feb 1 2007

ASJC Scopus subject areas

  • Clinical Neurology

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