Granulomatous interstitial nephritis associated with disseminated histoplasmosis in an immunocompetent patient

Qi Qian, Hamid Humayun, Youshay Humayun, Sanjeev M Sethi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We present a case of a 64-year-old man with a prolonged history of fatigue, weight loss, fever, and kidney failure. Kidney biopsy showed severe granulomatous interstitial nephritis with numerous giant cells. Silver stains identified fungal micro-organisms consistent with Histoplasma species. Despite antifungal treatment, the patient died of overwhelming infection a few weeks later. This report emphasizes the importance of diagnosing histoplasmosis early. A high degree of suspicion is required to make the diagnosis of histoplasmosis in a case of granulomatous interstitial nephritis.

Original languageEnglish (US)
Pages (from-to)1018-1021
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume58
Issue number6
DOIs
StatePublished - Dec 2011

Fingerprint

Interstitial Nephritis
Histoplasmosis
Histoplasma
Giant Cells
Silver
Renal Insufficiency
Fatigue
Weight Loss
Fever
Coloring Agents
Kidney
Biopsy
Infection
Therapeutics

Keywords

  • Granulomatous interstitial nephritis
  • Histoplasma

ASJC Scopus subject areas

  • Nephrology

Cite this

Granulomatous interstitial nephritis associated with disseminated histoplasmosis in an immunocompetent patient. / Qian, Qi; Humayun, Hamid; Humayun, Youshay; Sethi, Sanjeev M.

In: American Journal of Kidney Diseases, Vol. 58, No. 6, 12.2011, p. 1018-1021.

Research output: Contribution to journalArticle

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