TY - JOUR
T1 - Granuloma annulare in patients with malignant lymphoma
T2 - Clinicopathologic study of thirteen new cases
AU - Barksdale, Sarah Kay
AU - Perniciaro, Charles
AU - Halling, Kevin C.
AU - Stickler, John G.
PY - 1994
Y1 - 1994
N2 - Background: Reports of necrobiotic granulomas or granuloma annulare in patients with malignant lymphoma are rare. Objective: Our intent was to determine any unique clinical or histopathologic features in patients with granuloma annulare and lymphoma. Methods: We reviewed the medical records and biopsy material from 13 patients with granuloma annulare and lymphoma. Results: Three patients had Hodgkin's disease and 10 had non-Hodgkin's lymphoma. The granuloma annulare lesions showed typical histopathologic features. However, the clinical pattern was frequently atypical, with painful lesions in unusual locations including the palms and soles. Three patients displayed granulomatous inflammation in noncutaneous sites, either within the malignant lymphoma or in uninvolved tissues, and all three had atypical clinical presentations of granuloma annulare. Conclusion: Granuloma annulare with atypical clinical presentations may be associated with an underlying hematopoietic malignancy and may be part of a generalized granulomatous reaction to malignant lymphoma.
AB - Background: Reports of necrobiotic granulomas or granuloma annulare in patients with malignant lymphoma are rare. Objective: Our intent was to determine any unique clinical or histopathologic features in patients with granuloma annulare and lymphoma. Methods: We reviewed the medical records and biopsy material from 13 patients with granuloma annulare and lymphoma. Results: Three patients had Hodgkin's disease and 10 had non-Hodgkin's lymphoma. The granuloma annulare lesions showed typical histopathologic features. However, the clinical pattern was frequently atypical, with painful lesions in unusual locations including the palms and soles. Three patients displayed granulomatous inflammation in noncutaneous sites, either within the malignant lymphoma or in uninvolved tissues, and all three had atypical clinical presentations of granuloma annulare. Conclusion: Granuloma annulare with atypical clinical presentations may be associated with an underlying hematopoietic malignancy and may be part of a generalized granulomatous reaction to malignant lymphoma.
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U2 - 10.1016/S0190-9622(94)70133-4
DO - 10.1016/S0190-9622(94)70133-4
M3 - Article
C2 - 8021370
AN - SCOPUS:0028363509
SN - 0190-9622
VL - 31
SP - 42
EP - 48
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -