Granulocyte-macrophage colony-stimulating factor (GM-CSF) restores allostimulatory function to accessory cells in patients with AIDS

Zale P. Bernstein, Stephen P. Brooks, Asher A Chanan Khan, Sandra O. Gollnick, Mark J. Gilbert, Kena C. Miller, Thomas B. Tomasi

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1 Scopus citations

Abstract

Background: Impaired allostimulatory function of dendritic cells in patients with AIDS has been reported previously. Granulocyte-macrophage colony-stimulating factor (GM-CSF) can restore the T-cell stimulatory function in transforming growth factor-β1 (TGF-β1)-inhibited murine accessory cells. We now report the effect of intravenous recombinant human GM-CSF (rhGM-CSF) on accessory cells of HIV-infected patients. Method: The in vivo effect of GM-CSF on allostimulatory function of accessory cells was evaluated. Seventeen individuals with AIDS received a single infusion of rhGM-CSF (125 mg/m2 over 120 minutes). Samples of peripheral blood lymphocytes (PBL) were taken at 1, 5, and 24 hours after infusion, and the allostimulatory capacity was measured. Results: A single bolus infusion of rhGM-CSF resulted in significantly increased accessory cell function in 13/17 (88%) patients at one or more assayed time points after infusion. Conclusion: These results suggest that the administration of rhGM-CSF can potentially restore allostimulatory function to accessory cells in HIV-infected patients, and this presents a novel way of immune reconstitution. Clinical significance of this approach of immune reconstitution in AIDS patients warrants further investigations.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalHIV Clinical Trials
Volume3
Issue number3
StatePublished - 2002
Externally publishedYes

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Keywords

  • Accessory cells
  • AIDS
  • GM-CSF

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Bernstein, Z. P., Brooks, S. P., Chanan Khan, A. A., Gollnick, S. O., Gilbert, M. J., Miller, K. C., & Tomasi, T. B. (2002). Granulocyte-macrophage colony-stimulating factor (GM-CSF) restores allostimulatory function to accessory cells in patients with AIDS. HIV Clinical Trials, 3(3), 219-224.