Grandparent donors in a living related renal transplant program

Scott Nyberg, J. Carlos Manivel, Marie E. Cook, Kristen J. Gillingham, Arthur J. Matas, John S. Najarian

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Clinical renal transplantation is limited by the number of cadaver and living related donors. The use of kidneys from older donors and non-first-degree relatives, including grandparents, has increased the supply of organs for transplantation. The purpose of this study was to assess donor and recipient outcomes after living related renal transplants between grandparent donors and grandchild recipients. Fifteen living related renal transplants using grandparent donors were performed at the University of Minnesota from 1971 to 1995. All medical records from donors and recipients were retrospectively reviewed. In addition, all grandparents or, in one case, a surviving family member were contacted to obtain current information on medical health and feedback about the donation process. A current serum creatinine (Cr) level was obtained from 14 donors and 15 recipients. Statistical calculations were performed using the SAS system. Eleven grandmothers and four grand fathers, 34-70 yr old (mean, 55 yr) at the time of transplantation, donated a kidney to 15 grandchildren with end-stage renal disease. There were no major surgical complications in either group. One donor died from unrelated causes; the other 14 donors are alive with stable renal function (1.3 ± 0.3 mg/dL). Of 15 transplanted kidneys, 10 remain functional (Cr 1.3 ± 0.7 mg/dL) with 2- and 5-yr graft survival rates of 76% and 63%, respectively. Our results indicate that healthy grandparents provide an excellent population for living related kidney donation.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalClinical Transplantation
Volume11
Issue number5 I
StatePublished - Oct 1 1997
Externally publishedYes

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Keywords

  • Grandparent donors
  • Living related renal transplants
  • Organ shortage

ASJC Scopus subject areas

  • Transplantation

Cite this

Nyberg, S., Manivel, J. C., Cook, M. E., Gillingham, K. J., Matas, A. J., & Najarian, J. S. (1997). Grandparent donors in a living related renal transplant program. Clinical Transplantation, 11(5 I), 349-353.