Graft-vs.-host disease in lung and other solid organ transplant recipients

Maha A. Assi, Jose S Pulido, Steve G. Peters, Colin A. Mccannel, Raymund R Razonable

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Graft-vs.-host disease (GVHD) is an uncommon complication of solid organ transplantation. Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non-hepatic intra-abdominal organ transplantation. The major presenting clinical symptom of GVHD was skin rash. Less frequent clinical manifestations were cytopenia (16%), diarrhea (11%), and fever (5%). The mainstay of treatment was high-dose corticosteroids. The mortality rate was high (30%). The cause of death was mainly due to infection, suggesting that antimicrobial prophylaxis may improve the outcome of this potentially fatal complication.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalClinical Transplantation
Volume21
Issue number1
DOIs
StatePublished - Jan 2007

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Keywords

  • Chorioretinopathy
  • Graft-vs.-host
  • Graft-vs.-host disease
  • Solidorgan transplant

ASJC Scopus subject areas

  • Immunology
  • Transplantation

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