Graft vs. host disease after liver transplantation: A new approach is needed

Roman Perri; Maha Assi; Jayant Talwalkar; Julie Heimbach; William Hogan; S. Breanndan Moore; Charles B. Rosen

doi:10.1002/lt.21203

Graft vs. host disease after liver transplantation: A new approach is needed

Roman Perri, Maha Assi, Jayant Talwalkar, Julie Heimbach, William Hogan, S. Breanndan Moore, Charles B. Rosen

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Graft-vs.-host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis.

Original language	English (US)
Pages (from-to)	1092-1099
Number of pages	8
Journal	Liver Transplantation
Volume	13
Issue number	8
DOIs	https://doi.org/10.1002/lt.21203
State	Published - Aug 2007

ASJC Scopus subject areas

Surgery
Hepatology
Transplantation

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title = "Graft vs. host disease after liver transplantation: A new approach is needed",

abstract = "Graft-vs.-host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis.",

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T2 - A new approach is needed

AU - Perri, Roman

AU - Assi, Maha

AU - Talwalkar, Jayant

AU - Heimbach, Julie

AU - Hogan, William

AU - Moore, S. Breanndan

AU - Rosen, Charles B.

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AB - Graft-vs.-host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis.

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Graft vs. host disease after liver transplantation: A new approach is needed

Abstract

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