Graft vs. host disease after liver transplantation: A new approach is needed

Roman Perri, Maha Assi, Jayant Talwalkar, Julie Heimbach, William Hogan, S. Breanndan Moore, Charles B. Rosen

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Graft-vs.-host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis.

Original languageEnglish (US)
Pages (from-to)1092-1099
Number of pages8
JournalLiver Transplantation
Volume13
Issue number8
DOIs
StatePublished - Aug 2007

Fingerprint

Liver Transplantation
Transplants
Stem Cell Transplantation
Mortality
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Perri, R., Assi, M., Talwalkar, J., Heimbach, J., Hogan, W., Moore, S. B., & Rosen, C. B. (2007). Graft vs. host disease after liver transplantation: A new approach is needed. Liver Transplantation, 13(8), 1092-1099. https://doi.org/10.1002/lt.21203

Graft vs. host disease after liver transplantation : A new approach is needed. / Perri, Roman; Assi, Maha; Talwalkar, Jayant; Heimbach, Julie; Hogan, William; Moore, S. Breanndan; Rosen, Charles B.

In: Liver Transplantation, Vol. 13, No. 8, 08.2007, p. 1092-1099.

Research output: Contribution to journalArticle

Perri, R, Assi, M, Talwalkar, J, Heimbach, J, Hogan, W, Moore, SB & Rosen, CB 2007, 'Graft vs. host disease after liver transplantation: A new approach is needed', Liver Transplantation, vol. 13, no. 8, pp. 1092-1099. https://doi.org/10.1002/lt.21203
Perri, Roman ; Assi, Maha ; Talwalkar, Jayant ; Heimbach, Julie ; Hogan, William ; Moore, S. Breanndan ; Rosen, Charles B. / Graft vs. host disease after liver transplantation : A new approach is needed. In: Liver Transplantation. 2007 ; Vol. 13, No. 8. pp. 1092-1099.
@article{37b76bfab1624a3e958339bef30febd5,
title = "Graft vs. host disease after liver transplantation: A new approach is needed",
abstract = "Graft-vs.-host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis.",
author = "Roman Perri and Maha Assi and Jayant Talwalkar and Julie Heimbach and William Hogan and Moore, {S. Breanndan} and Rosen, {Charles B.}",
year = "2007",
month = "8",
doi = "10.1002/lt.21203",
language = "English (US)",
volume = "13",
pages = "1092--1099",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

TY - JOUR

T1 - Graft vs. host disease after liver transplantation

T2 - A new approach is needed

AU - Perri, Roman

AU - Assi, Maha

AU - Talwalkar, Jayant

AU - Heimbach, Julie

AU - Hogan, William

AU - Moore, S. Breanndan

AU - Rosen, Charles B.

PY - 2007/8

Y1 - 2007/8

N2 - Graft-vs.-host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis.

AB - Graft-vs.-host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=34548168799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548168799&partnerID=8YFLogxK

U2 - 10.1002/lt.21203

DO - 10.1002/lt.21203

M3 - Article

C2 - 17663410

AN - SCOPUS:34548168799

VL - 13

SP - 1092

EP - 1099

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 8

ER -