Graft-versus-host disease after orthotopic liver transplantation: Multivariate analysis of risk factors

Mohamed A. Elfeki, Surakit Pungpapong, Petrina V. Genco, Raouf E. Nakhleh, Justin H Nguyen, Denise Harnois

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Graft-versus-host disease (GVHD) is a rare, fatal complication following orthotopic liver transplantation (OLT). To date, several risk factors have been proposed, but reports on these factors have been inconclusive. This is a retrospective, case-control study of prospectively collected data from 2775 OLTs performed at our institution. Eight cases of GVHD after OLT were diagnosed on the basis of the patient's clinical characteristics, and the findings were confirmed with skin and colonic biopsies. Each case was matched to three controls based on the diagnosis of liver disease, recipient's age, and blood group. Univariate and multivariate analyses were performed to identify risk factors associated with the development of GVHD after OLT. The univariate and multivariate analyses identified two main risk factors associated with development of GVHD in OLT recipients, a difference between recipient and donor age of >20 yr, and any human leukocyte antigen class I matches. Taking these two risk factors into consideration while matching prospective donors and recipients may reduce further incidence of GVHD in OLT patients. However, further studies are recommended to validate these findings.

Original languageEnglish (US)
Pages (from-to)1063-1066
Number of pages4
JournalClinical Transplantation
Volume29
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • Graft-versus-host disease
  • Human leukocytic antigen
  • Multivariate analysis
  • Orthotopic liver transplantation

ASJC Scopus subject areas

  • Medicine(all)
  • Transplantation

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