Abstract
Graft-versus-host disease (GVHD) is a rare, fatal complication following orthotopic liver transplantation (OLT). To date, several risk factors have been proposed, but reports on these factors have been inconclusive. This is a retrospective, case-control study of prospectively collected data from 2775 OLTs performed at our institution. Eight cases of GVHD after OLT were diagnosed on the basis of the patient's clinical characteristics, and the findings were confirmed with skin and colonic biopsies. Each case was matched to three controls based on the diagnosis of liver disease, recipient's age, and blood group. Univariate and multivariate analyses were performed to identify risk factors associated with the development of GVHD after OLT. The univariate and multivariate analyses identified two main risk factors associated with development of GVHD in OLT recipients, a difference between recipient and donor age of >20 yr, and any human leukocyte antigen class I matches. Taking these two risk factors into consideration while matching prospective donors and recipients may reduce further incidence of GVHD in OLT patients. However, further studies are recommended to validate these findings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1063-1066 |
| Number of pages | 4 |
| Journal | Clinical Transplantation |
| Volume | 29 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2015 |
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Keywords
- Graft-versus-host disease
- Human leukocytic antigen
- Multivariate analysis
- Orthotopic liver transplantation
ASJC Scopus subject areas
- Medicine(all)
- Transplantation
Cite this
Graft-versus-host disease after orthotopic liver transplantation : Multivariate analysis of risk factors. / Elfeki, Mohamed A.; Pungpapong, Surakit; Genco, Petrina V.; Nakhleh, Raouf E.; Nguyen, Justin H; Harnois, Denise.
In: Clinical Transplantation, Vol. 29, No. 12, 01.12.2015, p. 1063-1066.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Graft-versus-host disease after orthotopic liver transplantation
T2 - Multivariate analysis of risk factors
AU - Elfeki, Mohamed A.
AU - Pungpapong, Surakit
AU - Genco, Petrina V.
AU - Nakhleh, Raouf E.
AU - Nguyen, Justin H
AU - Harnois, Denise
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Graft-versus-host disease (GVHD) is a rare, fatal complication following orthotopic liver transplantation (OLT). To date, several risk factors have been proposed, but reports on these factors have been inconclusive. This is a retrospective, case-control study of prospectively collected data from 2775 OLTs performed at our institution. Eight cases of GVHD after OLT were diagnosed on the basis of the patient's clinical characteristics, and the findings were confirmed with skin and colonic biopsies. Each case was matched to three controls based on the diagnosis of liver disease, recipient's age, and blood group. Univariate and multivariate analyses were performed to identify risk factors associated with the development of GVHD after OLT. The univariate and multivariate analyses identified two main risk factors associated with development of GVHD in OLT recipients, a difference between recipient and donor age of >20 yr, and any human leukocyte antigen class I matches. Taking these two risk factors into consideration while matching prospective donors and recipients may reduce further incidence of GVHD in OLT patients. However, further studies are recommended to validate these findings.
AB - Graft-versus-host disease (GVHD) is a rare, fatal complication following orthotopic liver transplantation (OLT). To date, several risk factors have been proposed, but reports on these factors have been inconclusive. This is a retrospective, case-control study of prospectively collected data from 2775 OLTs performed at our institution. Eight cases of GVHD after OLT were diagnosed on the basis of the patient's clinical characteristics, and the findings were confirmed with skin and colonic biopsies. Each case was matched to three controls based on the diagnosis of liver disease, recipient's age, and blood group. Univariate and multivariate analyses were performed to identify risk factors associated with the development of GVHD after OLT. The univariate and multivariate analyses identified two main risk factors associated with development of GVHD in OLT recipients, a difference between recipient and donor age of >20 yr, and any human leukocyte antigen class I matches. Taking these two risk factors into consideration while matching prospective donors and recipients may reduce further incidence of GVHD in OLT patients. However, further studies are recommended to validate these findings.
KW - Graft-versus-host disease
KW - Human leukocytic antigen
KW - Multivariate analysis
KW - Orthotopic liver transplantation
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UR - http://www.scopus.com/inward/citedby.url?scp=84983200764&partnerID=8YFLogxK
U2 - 10.1111/ctr.12627
DO - 10.1111/ctr.12627
M3 - Article
C2 - 26358521
AN - SCOPUS:84983200764
VL - 29
SP - 1063
EP - 1066
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
IS - 12
ER -