TY - JOUR
T1 - Graft thickness, graft folds, and aberrations after descemet stripping endothelial keratoplasty for fuchs dystrophy
AU - Seery, Loren S.
AU - Nau, Cherie B.
AU - McLaren, Jay W.
AU - Baratz, Keith H.
AU - Patel, Sanjay V.
N1 - Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, and none were reported. Publication of this article was supported by Research to Prevent Blindness, Inc , New York, NY (an unrestricted departmental grant, and S.V.P. as Olga Keith Wiess Special Scholar); Mayo Clinic Center for Translational Science Activities Grant Number UL1 RR024150 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), Bethesda, Maryland; and Mayo Foundation, Rochester, Minnesota. Involved in design of the study (J.W.M., K.H.B., S.V.P.); conduct of the study (L.S.S., C.B.N., J.W.M., K.H.B., S.V.P.); collection (L.S.S., C.B.N., K.H.B., S.V.P.), management (L.S.S., C.B.N., J.W.M., S.V.P.), analysis (J.W.M., K.H.B., S.V.P.), and interpretation (L.S.S., J.W.M., K.H.B., S.V.P.) of the data; and preparation (L.S.S., J.W.M., S.V.P.), review (L.S.S., C.B.N., J.W.M., K.H.B., S.V.P.), and approval (L.S.S., C.B.N., J.W.M., K.H.B., S.V.P.) of the manuscript. This study was approved by the Mayo Clinic Institutional Review Board and complied with the Health Insurance Portability and Accountability Act. Informed consent was obtained from all subjects. Statistical expertise was provided by David O. Hodge, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
PY - 2011/12
Y1 - 2011/12
N2 - Purpose: To determine whole-eye high-order aberrations (HOAs) in pseudophakic eyes after Descemet stripping endothelial keratoplasty (DSEK) for Fuchs dystrophy, and to establish relationships between graft thickness, HOAs, and visual acuity. Design: Cross-sectional study. Methods: Whole-eye HOAs were measured in pseudophakic eyes at intervals through 24 months after DSEK, and in otherwise healthy pseudophakic control eyes implanted with the same type of spherical intraocular lens. Wavefront errors were assessed by a Hartmann-Shack aberrometer over a 4-mm-diameter optical zone. In DSEK eyes, central graft thickness and stromal graft folds were measured using confocal microscopy in vivo, and best-corrected visual acuity (BCVA) was determined by the electronic Early Treatment of Diabetic Retinopathy Study method. Results: Total HOAs at 24 months after DSEK (0.28 ± 0.11 μm, mean ± SD, n = 17) were higher than those in pseudophakic controls (0.16 ± 0.07 μm, n = 25, P <.001); specifically, trefoil and quadrafoil were higher after DSEK. At 24 months, total HOAs (r = 0.69, P <.001) and graft folds (r = 0.41, P =.02) were correlated with central graft thickness, and BCVA was correlated with total HOAs (r = 0.39, P =.01) but not with graft thickness (r = -0.24, P =.20, n = 27). Conclusions: Whole-eye HOAs are higher after DSEK compared to untreated corneas. Thicker grafts are associated with increased HOAs and more graft folds, suggesting that the donor lenticule contributes, in part, to the wavefront errors. Although BCVA is weakly related to total HOAs after DSEK, it is not related to graft thickness.
AB - Purpose: To determine whole-eye high-order aberrations (HOAs) in pseudophakic eyes after Descemet stripping endothelial keratoplasty (DSEK) for Fuchs dystrophy, and to establish relationships between graft thickness, HOAs, and visual acuity. Design: Cross-sectional study. Methods: Whole-eye HOAs were measured in pseudophakic eyes at intervals through 24 months after DSEK, and in otherwise healthy pseudophakic control eyes implanted with the same type of spherical intraocular lens. Wavefront errors were assessed by a Hartmann-Shack aberrometer over a 4-mm-diameter optical zone. In DSEK eyes, central graft thickness and stromal graft folds were measured using confocal microscopy in vivo, and best-corrected visual acuity (BCVA) was determined by the electronic Early Treatment of Diabetic Retinopathy Study method. Results: Total HOAs at 24 months after DSEK (0.28 ± 0.11 μm, mean ± SD, n = 17) were higher than those in pseudophakic controls (0.16 ± 0.07 μm, n = 25, P <.001); specifically, trefoil and quadrafoil were higher after DSEK. At 24 months, total HOAs (r = 0.69, P <.001) and graft folds (r = 0.41, P =.02) were correlated with central graft thickness, and BCVA was correlated with total HOAs (r = 0.39, P =.01) but not with graft thickness (r = -0.24, P =.20, n = 27). Conclusions: Whole-eye HOAs are higher after DSEK compared to untreated corneas. Thicker grafts are associated with increased HOAs and more graft folds, suggesting that the donor lenticule contributes, in part, to the wavefront errors. Although BCVA is weakly related to total HOAs after DSEK, it is not related to graft thickness.
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U2 - 10.1016/j.ajo.2011.05.003
DO - 10.1016/j.ajo.2011.05.003
M3 - Article
C2 - 21803326
AN - SCOPUS:81855170006
SN - 0002-9394
VL - 152
SP - 910
EP - 916
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -