Graft thickness, graft folds, and aberrations after descemet stripping endothelial keratoplasty for fuchs dystrophy

Loren S. Seery, Cherie B. Nau, Jay W. McLaren, Keith Baratz, Sanjay V. Patel

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose: To determine whole-eye high-order aberrations (HOAs) in pseudophakic eyes after Descemet stripping endothelial keratoplasty (DSEK) for Fuchs dystrophy, and to establish relationships between graft thickness, HOAs, and visual acuity. Design: Cross-sectional study. Methods: Whole-eye HOAs were measured in pseudophakic eyes at intervals through 24 months after DSEK, and in otherwise healthy pseudophakic control eyes implanted with the same type of spherical intraocular lens. Wavefront errors were assessed by a Hartmann-Shack aberrometer over a 4-mm-diameter optical zone. In DSEK eyes, central graft thickness and stromal graft folds were measured using confocal microscopy in vivo, and best-corrected visual acuity (BCVA) was determined by the electronic Early Treatment of Diabetic Retinopathy Study method. Results: Total HOAs at 24 months after DSEK (0.28 ± 0.11 μm, mean ± SD, n = 17) were higher than those in pseudophakic controls (0.16 ± 0.07 μm, n = 25, P <.001); specifically, trefoil and quadrafoil were higher after DSEK. At 24 months, total HOAs (r = 0.69, P <.001) and graft folds (r = 0.41, P =.02) were correlated with central graft thickness, and BCVA was correlated with total HOAs (r = 0.39, P =.01) but not with graft thickness (r = -0.24, P =.20, n = 27). Conclusions: Whole-eye HOAs are higher after DSEK compared to untreated corneas. Thicker grafts are associated with increased HOAs and more graft folds, suggesting that the donor lenticule contributes, in part, to the wavefront errors. Although BCVA is weakly related to total HOAs after DSEK, it is not related to graft thickness.

Original languageEnglish (US)
Pages (from-to)910-916
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume152
Issue number6
DOIs
StatePublished - Dec 2011

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Descemet Stripping Endothelial Keratoplasty
Fuchs' Endothelial Dystrophy
Transplants
Visual Acuity
Intraocular Lenses
Diabetic Retinopathy
Confocal Microscopy
Cornea
Cross-Sectional Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Graft thickness, graft folds, and aberrations after descemet stripping endothelial keratoplasty for fuchs dystrophy. / Seery, Loren S.; Nau, Cherie B.; McLaren, Jay W.; Baratz, Keith; Patel, Sanjay V.

In: American Journal of Ophthalmology, Vol. 152, No. 6, 12.2011, p. 910-916.

Research output: Contribution to journalArticle

Seery, Loren S. ; Nau, Cherie B. ; McLaren, Jay W. ; Baratz, Keith ; Patel, Sanjay V. / Graft thickness, graft folds, and aberrations after descemet stripping endothelial keratoplasty for fuchs dystrophy. In: American Journal of Ophthalmology. 2011 ; Vol. 152, No. 6. pp. 910-916.
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abstract = "Purpose: To determine whole-eye high-order aberrations (HOAs) in pseudophakic eyes after Descemet stripping endothelial keratoplasty (DSEK) for Fuchs dystrophy, and to establish relationships between graft thickness, HOAs, and visual acuity. Design: Cross-sectional study. Methods: Whole-eye HOAs were measured in pseudophakic eyes at intervals through 24 months after DSEK, and in otherwise healthy pseudophakic control eyes implanted with the same type of spherical intraocular lens. Wavefront errors were assessed by a Hartmann-Shack aberrometer over a 4-mm-diameter optical zone. In DSEK eyes, central graft thickness and stromal graft folds were measured using confocal microscopy in vivo, and best-corrected visual acuity (BCVA) was determined by the electronic Early Treatment of Diabetic Retinopathy Study method. Results: Total HOAs at 24 months after DSEK (0.28 ± 0.11 μm, mean ± SD, n = 17) were higher than those in pseudophakic controls (0.16 ± 0.07 μm, n = 25, P <.001); specifically, trefoil and quadrafoil were higher after DSEK. At 24 months, total HOAs (r = 0.69, P <.001) and graft folds (r = 0.41, P =.02) were correlated with central graft thickness, and BCVA was correlated with total HOAs (r = 0.39, P =.01) but not with graft thickness (r = -0.24, P =.20, n = 27). Conclusions: Whole-eye HOAs are higher after DSEK compared to untreated corneas. Thicker grafts are associated with increased HOAs and more graft folds, suggesting that the donor lenticule contributes, in part, to the wavefront errors. Although BCVA is weakly related to total HOAs after DSEK, it is not related to graft thickness.",
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