TY - JOUR
T1 - Gold nanoparticles
T2 - Opportunities and challenges in nanomedicine
AU - Arvizo, Rochelle
AU - Bhattacharya, Resham
AU - Mukherjee, Priyabrata
N1 - Funding Information:
P Mukherjee’s work is partly supported by NIH CA135011 and CA136494 grants.
PY - 2010/6
Y1 - 2010/6
N2 - Importance of the field: Site-specific drug delivery is an important area of research that is anticipated to increase the efficacy of the drug and reduce potential side effects. Owing to this, substantial work has been done developing non-invasive and targeted tumor treatment with nanoscale metallic particles. Areas covered in this review: This review focuses on the work done in the last few years developing gold nanoparticles as cancer therapeutics and diagnostic agents. However, there are challenges in using gold nanoparticles as drug delivery systems, such as biodistribution, pharmacokinetics and possible toxicity. Approaches to limit these issues are proposed. What the reader will gain: Different approaches from several different disciplines are discussed. Potential clinical applications of these engineered nanoparticles are also presented. Take home message: As a result of their unique size-dependent physicochemical and optical properties, adaptability, subcellular size and biocompatibility, these nanosized carriers offer a suitable means of transporting small molecules as well as biomacromolecules to diseased cells/tissues.
AB - Importance of the field: Site-specific drug delivery is an important area of research that is anticipated to increase the efficacy of the drug and reduce potential side effects. Owing to this, substantial work has been done developing non-invasive and targeted tumor treatment with nanoscale metallic particles. Areas covered in this review: This review focuses on the work done in the last few years developing gold nanoparticles as cancer therapeutics and diagnostic agents. However, there are challenges in using gold nanoparticles as drug delivery systems, such as biodistribution, pharmacokinetics and possible toxicity. Approaches to limit these issues are proposed. What the reader will gain: Different approaches from several different disciplines are discussed. Potential clinical applications of these engineered nanoparticles are also presented. Take home message: As a result of their unique size-dependent physicochemical and optical properties, adaptability, subcellular size and biocompatibility, these nanosized carriers offer a suitable means of transporting small molecules as well as biomacromolecules to diseased cells/tissues.
KW - Biodistribution
KW - Cancer
KW - Diagnostics
KW - Drug delivery
KW - Drug targeting
KW - Gold nanoparticles
KW - Photodynamic therapy
KW - Thermal ablation
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U2 - 10.1517/17425241003777010
DO - 10.1517/17425241003777010
M3 - Review article
C2 - 20408736
AN - SCOPUS:77952678352
SN - 1742-5247
VL - 7
SP - 753
EP - 763
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
IS - 6
ER -