Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells

R. Bhattacharya, P. Mukherjee, Z. Xiong, A. Atala, S. Soker, D. Mukhopadhyay

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. The interaction between gold nanoparticles and VEGF165 primarily occurs through the heparin binding domain of the protein. VEGF121 does not have a heparin binding domain and hence is not inactivated by gold nanoparticles.

Original languageEnglish (US)
Pages (from-to)2479-2481
Number of pages3
JournalNano Letters
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2004

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Bhattacharya, R., Mukherjee, P., Xiong, Z., Atala, A., Soker, S., & Mukhopadhyay, D. (2004). Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells. Nano Letters, 4(12), 2479-2481. https://doi.org/10.1021/nl0483789