Gold nanoparticles inhibit the proliferation of multiple myeloma cells

Resham Bhattacharya; Chitta Ranjan Patra; Rajanshu Verma; Shaji Kumar; Philip R. Greipp; Priyabrata Mukherjee

doi:10.1002/adma.200602098

Gold nanoparticles inhibit the proliferation of multiple myeloma cells

Resham Bhattacharya, Chitta Ranjan Patra, Rajanshu Verma, Shaji Kumar, Philip R. Greipp, Priyabrata Mukherjee

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Multiple myeloma (MM), a monoclonal plasma-cell malignancy characterized by levels of pararproteins in blood and/or urine, lytic bone lesions, anemia, renal dysfunction, and cytokines, remains universally fatal. The treatments for this disease include combination therapy with or without stem cell transplantation, use of alkylating agents, glucocortisteroids, and thalidomide. The application of gold nanoparticles (GNP) that remarkably inhibits the proliferation of MM cells lines is tested in a dose-dependent manner. The UV-visible spectrum of GNP is formed by using the sodium borohydride reduction method. A characteristic surface-plasmon resonance band of GNP indicates the formation of GNPs. The transmission electron microscopy (TEM) picture shows that spherical GNPs of nearly 5 nm are formed by using the method.

Original language	English (US)
Pages (from-to)	711-716
Number of pages	6
Journal	Advanced Materials
Volume	19
Issue number	5
DOIs	https://doi.org/10.1002/adma.200602098
State	Published - Mar 5 2007

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.200602098

Cite this

@article{9714ce3b7c5b40ebaca18e24aa9fa306,

title = "Gold nanoparticles inhibit the proliferation of multiple myeloma cells",

abstract = "Multiple myeloma (MM), a monoclonal plasma-cell malignancy characterized by levels of pararproteins in blood and/or urine, lytic bone lesions, anemia, renal dysfunction, and cytokines, remains universally fatal. The treatments for this disease include combination therapy with or without stem cell transplantation, use of alkylating agents, glucocortisteroids, and thalidomide. The application of gold nanoparticles (GNP) that remarkably inhibits the proliferation of MM cells lines is tested in a dose-dependent manner. The UV-visible spectrum of GNP is formed by using the sodium borohydride reduction method. A characteristic surface-plasmon resonance band of GNP indicates the formation of GNPs. The transmission electron microscopy (TEM) picture shows that spherical GNPs of nearly 5 nm are formed by using the method.",

author = "Resham Bhattacharya and Patra, {Chitta Ranjan} and Rajanshu Verma and Shaji Kumar and Greipp, {Philip R.} and Priyabrata Mukherjee",

year = "2007",

month = mar,

day = "5",

doi = "10.1002/adma.200602098",

language = "English (US)",

volume = "19",

pages = "711--716",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "5",

}

TY - JOUR

T1 - Gold nanoparticles inhibit the proliferation of multiple myeloma cells

AU - Bhattacharya, Resham

AU - Patra, Chitta Ranjan

AU - Verma, Rajanshu

AU - Kumar, Shaji

AU - Greipp, Philip R.

AU - Mukherjee, Priyabrata

PY - 2007/3/5

Y1 - 2007/3/5

N2 - Multiple myeloma (MM), a monoclonal plasma-cell malignancy characterized by levels of pararproteins in blood and/or urine, lytic bone lesions, anemia, renal dysfunction, and cytokines, remains universally fatal. The treatments for this disease include combination therapy with or without stem cell transplantation, use of alkylating agents, glucocortisteroids, and thalidomide. The application of gold nanoparticles (GNP) that remarkably inhibits the proliferation of MM cells lines is tested in a dose-dependent manner. The UV-visible spectrum of GNP is formed by using the sodium borohydride reduction method. A characteristic surface-plasmon resonance band of GNP indicates the formation of GNPs. The transmission electron microscopy (TEM) picture shows that spherical GNPs of nearly 5 nm are formed by using the method.

AB - Multiple myeloma (MM), a monoclonal plasma-cell malignancy characterized by levels of pararproteins in blood and/or urine, lytic bone lesions, anemia, renal dysfunction, and cytokines, remains universally fatal. The treatments for this disease include combination therapy with or without stem cell transplantation, use of alkylating agents, glucocortisteroids, and thalidomide. The application of gold nanoparticles (GNP) that remarkably inhibits the proliferation of MM cells lines is tested in a dose-dependent manner. The UV-visible spectrum of GNP is formed by using the sodium borohydride reduction method. A characteristic surface-plasmon resonance band of GNP indicates the formation of GNPs. The transmission electron microscopy (TEM) picture shows that spherical GNPs of nearly 5 nm are formed by using the method.

UR - http://www.scopus.com/inward/record.url?scp=34250632444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250632444&partnerID=8YFLogxK

U2 - 10.1002/adma.200602098

DO - 10.1002/adma.200602098

M3 - Article

AN - SCOPUS:34250632444

SN - 0935-9648

VL - 19

SP - 711

EP - 716

JO - Advanced Materials

JF - Advanced Materials

IS - 5

ER -

Gold nanoparticles inhibit the proliferation of multiple myeloma cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this