Glypican-5 is a tumor suppressor in non-small cell lung cancer cells

Lixia Guo, Jingyu Wang, Ting Zhang, Yanan D Yang

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Glypican-5 (GPC5) belongs to the glypican family of proteoglycans that have been implicated in a variety of physiological processes, ranging from cell proliferation to morphogenesis. However, the role of GPC5 in human cancer remains poorly understood. We report that knockdown of GPC5 in bronchial epithelial cells promoted, and forced expression of GPC5 in non-small lung cancer (NSCLC) cells suppressed, the anchorage-independent cell growth. In vivo, expression of GPC5 inhibited xenograft tumor growth of NSCLC cells. Furthermore, we found that GPC5 was expressed predominantly as a membrane protein, and its expression led to diminished phosphorylation of several oncogenic receptor tyrosine kinases, including the ERBB family members ERBB2 and ERBB3, which play critical roles in lung tumorigenesis. Collectively, our results suggest that GPC5 may act as a tumor suppressor, and reagents that activate GPC5 may be useful for treating NSCLC.

Original languageEnglish (US)
Pages (from-to)108-112
Number of pages5
JournalBiochemistry and Biophysics Reports
Volume6
DOIs
StatePublished - Jul 1 2016

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Keywords

  • Cell signaling
  • Glypican-5
  • Lung cancer
  • Tumor suppressor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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