Glycogenic Hepatopathy

Research output: Contribution to journalReview article

Abstract

Glycogenic hepatopathy results from the pathologic accumulation of excess glycogen within the liver and is most commonly associated with poorly controlled type I diabetes mellitus. Additional patient groups that can be affected by glycogenic hepatopathy include those with type II diabetes mellitus, urea cycle defects, and drug effect. The clinical presentation typically includes varying degrees of hepatomegaly, abdominal pain, and elevated transaminases. Occasionally, the transaminase elevations can be dramatic and reach levels of greater than 10 times the upper limit of normal. The liver shows diffusely pale staining hepatocytes on routine H&E stains and excessive glycogen accumulation on PAS stains. Abundant glycogenated nuclei and megamitochondria can be seen, but there should be little or no inflammation, mild or absent fatty change, and no significant fibrosis. Other clinical and histologic lesions associated with abnormal glycogen accumulation include genetic glycogen storage disease, glycogen storing foci, and pseudo-ground glass change.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalPathology Case Reviews
Volume15
Issue number3
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Glycogen
Transaminases
Coloring Agents
Glycogen Storage Disease
Liver Glycogen
Hepatomegaly
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Abdominal Pain
Glass
Urea
Hepatocytes
Fibrosis
Staining and Labeling
Inflammation
Liver
Pharmaceutical Preparations

Keywords

  • Diabetes mellitus
  • Glycogen
  • Glycogenic hepatopathy
  • Glycogenosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Glycogenic Hepatopathy. / Torbenson, Michael.

In: Pathology Case Reviews, Vol. 15, No. 3, 01.05.2010, p. 72-76.

Research output: Contribution to journalReview article

Torbenson, Michael. / Glycogenic Hepatopathy. In: Pathology Case Reviews. 2010 ; Vol. 15, No. 3. pp. 72-76.
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