TY - JOUR
T1 - Glycemic responses to sweetened dried and raw cranberries in humans with type 2 diabetes
AU - Wilson, Ted
AU - Luebke, Justin L.
AU - Morcomb, Erin F.
AU - Carrell, Emily J.
AU - Leveranz, Megan C.
AU - Kobs, Lisa
AU - Schmidt, Travis P.
AU - Limburg, Paul J.
AU - Vorsa, Nicholi
AU - Singh, Ajay P.
PY - 2010/10
Y1 - 2010/10
N2 - This study assessed the metabolic response to sweetened dried cranberries (SDC), raw cranberries (RC), and white bread (WB) in humans with type 2 diabetes. Development of palatable cranberry preparations associated with lower glycemic responses may be useful for improving fruit consumption and glycemic control among those with diabetes. In this trial, type 2 diabetics (n = 13) received WB (57g, 160 cal, 1g fiber), RC (55g, 21 cal, 1g fiber), SDC (40g, 138 cal, 2.1g fiber), and SDC containing less sugar (SDC-LS, 40g, 113 cal, 1.8g fiber + 10g polydextrose). Plasma glucose (mmol/L) peaked significantly at 60min for WB, and at 30min for RC, SDC, and SDC-LS at 9.6 ± 0.4, 7.0 ± 0.4, 9.6 ± 0.5, and 8.7 ± 0.5, respectively, WB remained significantly elevated from the other treatments at 120min. Plasma insulin (pmol/mL) peaked at 60min for WB and SDC and at 30min for RC and SDC-LS at 157 ± 15, 142 ± 27, 61 ± 8, and 97 ± 11, respectively. Plasma insulin for SDC-LS was significantly lower at 60min than either WB or SDC. Insulin area under the curve (AUC) values for RC and SDC-LS were both significantly lower than WB or SDC. Phenolic content of SDC and SDC-LS was determined following extraction with 80% acetone prior to high-performance liquid chromatography (HPLC) and electronspray ionization-mass spectrometry (ESI-MS) and found to be rich in 5-caffeoylquinic cid, quercetin-3-galactoside, and quercetin-3-galactoside, and the proanthocyanidin dimer epicatechin. In conclusion, SDC-LS was associated with a favorable glycemic and insulinemic response in type 2 diabetics.
AB - This study assessed the metabolic response to sweetened dried cranberries (SDC), raw cranberries (RC), and white bread (WB) in humans with type 2 diabetes. Development of palatable cranberry preparations associated with lower glycemic responses may be useful for improving fruit consumption and glycemic control among those with diabetes. In this trial, type 2 diabetics (n = 13) received WB (57g, 160 cal, 1g fiber), RC (55g, 21 cal, 1g fiber), SDC (40g, 138 cal, 2.1g fiber), and SDC containing less sugar (SDC-LS, 40g, 113 cal, 1.8g fiber + 10g polydextrose). Plasma glucose (mmol/L) peaked significantly at 60min for WB, and at 30min for RC, SDC, and SDC-LS at 9.6 ± 0.4, 7.0 ± 0.4, 9.6 ± 0.5, and 8.7 ± 0.5, respectively, WB remained significantly elevated from the other treatments at 120min. Plasma insulin (pmol/mL) peaked at 60min for WB and SDC and at 30min for RC and SDC-LS at 157 ± 15, 142 ± 27, 61 ± 8, and 97 ± 11, respectively. Plasma insulin for SDC-LS was significantly lower at 60min than either WB or SDC. Insulin area under the curve (AUC) values for RC and SDC-LS were both significantly lower than WB or SDC. Phenolic content of SDC and SDC-LS was determined following extraction with 80% acetone prior to high-performance liquid chromatography (HPLC) and electronspray ionization-mass spectrometry (ESI-MS) and found to be rich in 5-caffeoylquinic cid, quercetin-3-galactoside, and quercetin-3-galactoside, and the proanthocyanidin dimer epicatechin. In conclusion, SDC-LS was associated with a favorable glycemic and insulinemic response in type 2 diabetics.
KW - Diabetes
KW - Health
KW - Ingredients
KW - Nutrition
KW - Phenolic compounds
UR - http://www.scopus.com/inward/record.url?scp=77958616468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958616468&partnerID=8YFLogxK
U2 - 10.1111/j.1750-3841.2010.01800.x
DO - 10.1111/j.1750-3841.2010.01800.x
M3 - Article
C2 - 21535498
AN - SCOPUS:77958616468
SN - 0022-1147
VL - 75
SP - H218-H223
JO - Journal of Food Science
JF - Journal of Food Science
IS - 8
ER -