TY - JOUR
T1 - Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes
AU - Rianon, Nahid J.
AU - Smith, Scott M.
AU - Lee, Min Jae
AU - Pervin, Hannah
AU - Musgrave, Paul
AU - Watt, Gordon P.
AU - Nader, Shahla
AU - Khosla, Sundeep
AU - Ambrose, Catherine G.
AU - McCormick, Joseph B.
AU - Fisher-Hoch, Susan P.
N1 - Funding Information:
The authors gratefully acknowledge support provided by a grants from (1) the Clinical Center for Translational Sciences (CCTS), the University of Texas Health Science Center at Houston; and (2) Albert and Ethel Herzstein Charitable Foundation for Geriatric Studies for Junior Faculty Program. The authors thank the NASA Nutritional Biochemistry Lab for support of the biochemical testing and Jane Krauhs for editing assistance.
Publisher Copyright:
© 2018 Nahid J. Rianon et al.
PY - 2018
Y1 - 2018
N2 - Altered bone quality, caused by underlying metabolic changes of type 2 diabetes (T2D), has been hypothesized to cause altered bone strength and turnover leading to increased fracture risk in T2D patients. Current understanding about changes in bone turnover markers in T2D patients is mainly based on studies focused on Caucasian men and women. However, Hispanic populations have the highest prevalence of both T2D and osteoporosis in the US. We investigated associations of glycemic control (in terms of glycated hemoglobin [HbA1c]) and bone turnover rate in 69 older (≥50 years) Mexican American Cameron County Hispanic Cohort (CCHC) participants with T2D. Multivariable analyses were conducted to assess the associations between HbA1c (%), serum osteocalcin (OC), and serum sclerostin. In agreement with published reports from other racial/ethnic populations, our study found that lower bone turnover (indicated by lower serum OC) occurred in Mexican American men with T2D who had poorer glycemic control. For the women in our study, we found no significant association between glycemic control and OC. In contrast, HbA1c was positively associated with sclerostin for women, with near significance (p=0.07), while no association was found in men. We recommend screening Mexican American individuals with T2D, specifically those with poor glycemic control, for bone loss and fracture risk.
AB - Altered bone quality, caused by underlying metabolic changes of type 2 diabetes (T2D), has been hypothesized to cause altered bone strength and turnover leading to increased fracture risk in T2D patients. Current understanding about changes in bone turnover markers in T2D patients is mainly based on studies focused on Caucasian men and women. However, Hispanic populations have the highest prevalence of both T2D and osteoporosis in the US. We investigated associations of glycemic control (in terms of glycated hemoglobin [HbA1c]) and bone turnover rate in 69 older (≥50 years) Mexican American Cameron County Hispanic Cohort (CCHC) participants with T2D. Multivariable analyses were conducted to assess the associations between HbA1c (%), serum osteocalcin (OC), and serum sclerostin. In agreement with published reports from other racial/ethnic populations, our study found that lower bone turnover (indicated by lower serum OC) occurred in Mexican American men with T2D who had poorer glycemic control. For the women in our study, we found no significant association between glycemic control and OC. In contrast, HbA1c was positively associated with sclerostin for women, with near significance (p=0.07), while no association was found in men. We recommend screening Mexican American individuals with T2D, specifically those with poor glycemic control, for bone loss and fracture risk.
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U2 - 10.1155/2018/7153021
DO - 10.1155/2018/7153021
M3 - Article
AN - SCOPUS:85047882715
SN - 2090-8059
VL - 2018
JO - Journal of Osteoporosis
JF - Journal of Osteoporosis
M1 - 7153021
ER -