Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress

S. D. Yan, X. Chen, A. M. Schmidt, J. Brett, G. Godman, Y. S. Zou, C. W. Scott, C. Caputo, T. Frappier, M. A. Smith, G. Perry, S. H. Yen, D. Stern

Research output: Contribution to journalArticle

504 Scopus citations

Abstract

The stability of proteins that constitute the neurofibrillary tangles and senile plaques of Alzheimer disease suggests that they would be ideal substrates for nonenzymatic glycation, a process that occurs over long times, even at normal levels of glucose, ultimately resulting in the formation of advanced glycation end products (AGEs). AGE-modified proteins aggregate, and they generate reactive oxygen intermediates. Using monospecific antibody to AGEs, we have colocalized these AGEs with paired helical filament tau in neurofibrillary tangles in sporadic Alzheimer disease. Such neurons also exhibited evidence of oxidant stress: induction of malondialdehyde epitopes and heme oxygenase 1 antigen. AGE-recombinant tau generated reactive oxygen intermediates and, when introduced into the cytoplasm of SH-SY5Y neuroblastoma cells, induced oxidant stress. We propose that in Alzheimer disease, AGEs in paired helical filament tau can induce oxidant stress, thereby promoting neuronal dysfunction.

Original languageEnglish (US)
Pages (from-to)7787-7791
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number16
DOIs
StatePublished - Aug 2 1994

Keywords

  • glycation
  • neuron
  • reactive oxygen intermediate

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress'. Together they form a unique fingerprint.

  • Cite this

    Yan, S. D., Chen, X., Schmidt, A. M., Brett, J., Godman, G., Zou, Y. S., Scott, C. W., Caputo, C., Frappier, T., Smith, M. A., Perry, G., Yen, S. H., & Stern, D. (1994). Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress. Proceedings of the National Academy of Sciences of the United States of America, 91(16), 7787-7791. https://doi.org/10.1073/pnas.91.16.7787