Abstract
Glutathione S-transferase pi gene methylation has recently been described in prostatic adenocarcinoma. Aggregate data on 115 samples studied to date have found an 87% sensitivity and 92% specificity for prostate cancer diagnosis. The current literature about this new marker is herein summarized, and possible molecular mechanisms by which glutathione S-transferase pi may participate in prostatic carcinogenesis are reviewed. The possible clinical implications of this molecular alteration in the diagnosis of prostatic adenocarcinoma are also studied.
Original language | English (US) |
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Pages (from-to) | 382-389 |
Number of pages | 8 |
Journal | Advances in anatomic pathology |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2000 |
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine