Glutathione S-transferase pi gene methylation: the search for a molecular marker of prostatic adenocarcinoma.

R. E. Jimenez, A. H. Fischer, J. A. Petros, M. B. Amin

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Glutathione S-transferase pi gene methylation has recently been described in prostatic adenocarcinoma. Aggregate data on 115 samples studied to date have found an 87% sensitivity and 92% specificity for prostate cancer diagnosis. The current literature about this new marker is herein summarized, and possible molecular mechanisms by which glutathione S-transferase pi may participate in prostatic carcinogenesis are reviewed. The possible clinical implications of this molecular alteration in the diagnosis of prostatic adenocarcinoma are also studied.

Original languageEnglish (US)
Pages (from-to)382-389
Number of pages8
JournalAdvances in anatomic pathology
Volume7
Issue number6
DOIs
StatePublished - Nov 2000

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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