Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population

M. Toft, L. Pielsticker, O. A. Ross, J. O. Aasly, M. J. Farrer

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

An association between mutations in the glucocerebrosidase (GBA) gene and Parkinson disease (PD) was recently reported in Ashkenazi Jews. The authors screened a series of 311 Norwegian patients with PD and 474 controls for 2 common functional mutations of the GBA protein, N370S and L444P. Seven patients (2.3%) and 8 controls (1.7%) carried a mutant GBA allele (p = 0.58). This study does not indicate increased susceptibility to PD in GBA mutations carriers in Norway.

Original languageEnglish (US)
Pages (from-to)415-417
Number of pages3
JournalNeurology
Volume66
Issue number3
DOIs
StatePublished - Feb 1 2006

ASJC Scopus subject areas

  • Clinical Neurology

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