Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population

M. Toft, L. Pielsticker, Owen A Ross, J. O. Aasly, M. J. Farrer

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

An association between mutations in the glucocerebrosidase (GBA) gene and Parkinson disease (PD) was recently reported in Ashkenazi Jews. The authors screened a series of 311 Norwegian patients with PD and 474 controls for 2 common functional mutations of the GBA protein, N370S and L444P. Seven patients (2.3%) and 8 controls (1.7%) carried a mutant GBA allele (p = 0.58). This study does not indicate increased susceptibility to PD in GBA mutations carriers in Norway.

Original languageEnglish (US)
Pages (from-to)415-417
Number of pages3
JournalNeurology
Volume66
Issue number3
DOIs
StatePublished - Feb 2006

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Glucosylceramidase
Parkinson Disease
Mutation
Population
Genes
Jews
Norway
Alleles
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population. / Toft, M.; Pielsticker, L.; Ross, Owen A; Aasly, J. O.; Farrer, M. J.

In: Neurology, Vol. 66, No. 3, 02.2006, p. 415-417.

Research output: Contribution to journalArticle

Toft, M. ; Pielsticker, L. ; Ross, Owen A ; Aasly, J. O. ; Farrer, M. J. / Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population. In: Neurology. 2006 ; Vol. 66, No. 3. pp. 415-417.
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