Global tests in the additive hazards regression model

Axel Gandy, Terry M Therneau, Odd O. Aalen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this article, we discuss testing for the effect of several covariates in the additive hazards regression model. Bhattacharyya and Klein (Statist. Med. 2005; 24(14):2235-2240) note that an ad hoc weight function suggested by Aalen (Statist. Med. 1989; 8:907-925) is inconsistent when used as a global test for comparing groups since the test statistic depends on which group is used as the baseline group. We will suggest a simple alternative test that does not exhibit this problem. This test is a natural extension of the logrank test. We shall also discuss an alternative covariance estimator. The tests are applied to a data set and a simulation study is performed.

Original languageEnglish (US)
Pages (from-to)831-844
Number of pages14
JournalStatistics in Medicine
Volume27
Issue number6
DOIs
StatePublished - Mar 15 2008

Fingerprint

Hazard Models
Proportional Hazards Models
Regression Model
Weights and Measures
Log-rank Test
Alternatives
Natural Extension
Weight Function
Inconsistent
Test Statistic
Covariates
Baseline
Simulation Study
Estimator
Testing
Datasets

Keywords

  • Additive model
  • Logrank test
  • Survival analysis

ASJC Scopus subject areas

  • Epidemiology

Cite this

Global tests in the additive hazards regression model. / Gandy, Axel; Therneau, Terry M; Aalen, Odd O.

In: Statistics in Medicine, Vol. 27, No. 6, 15.03.2008, p. 831-844.

Research output: Contribution to journalArticle

Gandy, Axel ; Therneau, Terry M ; Aalen, Odd O. / Global tests in the additive hazards regression model. In: Statistics in Medicine. 2008 ; Vol. 27, No. 6. pp. 831-844.
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