Global tests in the additive hazards regression model

Axel Gandy, Terry M. Therneau, Odd O. Aalen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In this article, we discuss testing for the effect of several covariates in the additive hazards regression model. Bhattacharyya and Klein (Statist. Med. 2005; 24(14):2235-2240) note that an ad hoc weight function suggested by Aalen (Statist. Med. 1989; 8:907-925) is inconsistent when used as a global test for comparing groups since the test statistic depends on which group is used as the baseline group. We will suggest a simple alternative test that does not exhibit this problem. This test is a natural extension of the logrank test. We shall also discuss an alternative covariance estimator. The tests are applied to a data set and a simulation study is performed.

Original languageEnglish (US)
Pages (from-to)831-844
Number of pages14
JournalStatistics in Medicine
Volume27
Issue number6
DOIs
StatePublished - Mar 15 2008

Keywords

  • Additive model
  • Logrank test
  • Survival analysis

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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