Abstract
Background: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. Objectives: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. Methods: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Results: In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. Conclusions: CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.
| Original language | English (US) |
|---|---|
| Journal | Journal of the American College of Cardiology |
| DOIs | |
| State | Accepted/In press - Mar 8 2017 |
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Keywords
- Cause of death
- Epidemiology
- Global health
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. / Roth, Gregory A.; Johnson, Catherine; Abajobir, Amanuel; Abd-Allah, Foad; Abera, Semaw Ferede; Abyu, Gebre; Ahmed, Muktar; Aksut, Baran; Alam, Tahiya; Alam, Khurshid; Alla, François; Alvis-Guzman, Nelson; Amrock, Stephen; Ansari, Hossein; Ärnlöv, Johan; Asayesh, Hamid; Atey, Tesfay Mehari; Avila-Burgos, Leticia; Awasthi, Ashish; Banerjee, Amitava; Barac, Aleksandra; Bärnighausen, Till; Barregard, Lars; Bedi, Neeraj; Belay Ketema, Ezra; Bennett, Derrick; Berhe, Gebremedhin; Bhutta, Zulfiqar; Bitew, Shimelash; Carapetis, Jonathan; Carrero, Juan Jesus; Malta, Deborah Carvalho; Castañeda-Orjuela, Carlos Andres; Castillo-Rivas, Jacqueline; Catalá-López, Ferrán; Choi, Jee Young; Christensen, Hanne; Cirillo, Massimo; Cooper, Leslie T Jr.; Criqui, Michael; Cundiff, David; Damasceno, Albertino; Dandona, Lalit; Dandona, Rakhi; Davletov, Kairat; Dharmaratne, Samath; Dorairaj, Prabhakaran; Dubey, Manisha; Ehrenkranz, Rebecca; El Sayed Zaki, Maysaa; Faraon, Emerito Jose A.; Esteghamati, Alireza; Farid, Talha; Farvid, Maryam; Feigin, Valery; Ding, Eric L.; Fowkes, Gerry; Gebrehiwot, Tsegaye; Gillum, Richard; Gold, Audra; Gona, Philimon; Gupta, Rajeev; Habtewold, Tesfa Dejenie; Hafezi-Nejad, Nima; Hailu, Tesfaye; Hailu, Gessessew Bugssa; Hankey, Graeme; Hassen, Hamid Yimam; Abate, Kalkidan Hassen; Havmoeller, Rasmus; Hay, Simon I.; Horino, Masako; Hotez, Peter J.; Jacobsen, Kathryn; James, Spencer; Javanbakht, Mehdi; Jeemon, Panniyammakal; John, Denny; Jonas, Jost; Kalkonde, Yogeshwar; Karimkhani, Chante; Kasaeian, Amir; Khader, Yousef; Khan, Abdur; Khang, Young Ho; Khera, Sahil; Khoja, Abdullah T.; Khubchandani, Jagdish; Kim, Daniel; Kolte, Dhaval; Kosen, Soewarta; Krohn, Kristopher J.; Kumar, G. Anil; Kwan, Gene; Lal, Dharmesh Kumar; Larsson, Anders; Linn, Shai; Lopez, Alan; Lotufo, Paulo A.; El Razek, Hassan Magdy Abd; Malekzadeh, Reza; Mazidi, Mohsen; Meier, Toni; Meles, Kidanu Gebremariam; Mensah, George; Meretoja, Atte; Mezgebe, Haftay; Miller, Ted; Mirrakhimov, Erkin; Mohammed, Shafiu; Moran, Andrew E.; Musa, Kamarul Imran; Narula, Jagat; Neal, Bruce; Ngalesoni, Frida; Nguyen, Grant; Obermeyer, Carla Makhlouf; Owolabi, Mayowa; Patton, George; Pedro, João; Qato, Dima; Qorbani, Mostafa; Rahimi, Kazem; Rai, Rajesh Kumar; Rawaf, Salman; Ribeiro, Antônio; Safiri, Saeid; Salomon, Joshua A.; Santos, Itamar; Santric Milicevic, Milena; Sartorius, Benn; Schutte, Aletta; Sepanlou, Sadaf; Shaikh, Masood Ali; Shin, Min Jeong; Shishehbor, Mehdi; Shore, Hirbo; Silva, Diego Augusto Santos; Sobngwi, Eugene; Stranges, Saverio; Swaminathan, Soumya; Tabarés-Seisdedos, Rafael; Tadele Atnafu, Niguse; Tesfay, Fisaha; Thakur, J. S.; Thrift, Amanda; Topor-Madry, Roman; Truelsen, Thomas; Tyrovolas, Stefanos; Ukwaja, Kingsley Nnanna; Uthman, Olalekan; Vasankari, Tommi; Vlassov, Vasiliy; Vollset, Stein Emil; Wakayo, Tolassa; Watkins, David; Weintraub, Robert; Werdecker, Andrea; Westerman, Ronny; Wiysonge, Charles Shey; Wolfe, Charles; Workicho, Abdulhalik; Xu, Gelin; Yano, Yuichiro; Yip, Paul; Yonemoto, Naohiro; Younis, Mustafa; Yu, Chuanhua; Vos, Theo; Naghavi, Mohsen; Murray, Christopher.
In: Journal of the American College of Cardiology, 08.03.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
AU - Roth, Gregory A.
AU - Johnson, Catherine
AU - Abajobir, Amanuel
AU - Abd-Allah, Foad
AU - Abera, Semaw Ferede
AU - Abyu, Gebre
AU - Ahmed, Muktar
AU - Aksut, Baran
AU - Alam, Tahiya
AU - Alam, Khurshid
AU - Alla, François
AU - Alvis-Guzman, Nelson
AU - Amrock, Stephen
AU - Ansari, Hossein
AU - Ärnlöv, Johan
AU - Asayesh, Hamid
AU - Atey, Tesfay Mehari
AU - Avila-Burgos, Leticia
AU - Awasthi, Ashish
AU - Banerjee, Amitava
AU - Barac, Aleksandra
AU - Bärnighausen, Till
AU - Barregard, Lars
AU - Bedi, Neeraj
AU - Belay Ketema, Ezra
AU - Bennett, Derrick
AU - Berhe, Gebremedhin
AU - Bhutta, Zulfiqar
AU - Bitew, Shimelash
AU - Carapetis, Jonathan
AU - Carrero, Juan Jesus
AU - Malta, Deborah Carvalho
AU - Castañeda-Orjuela, Carlos Andres
AU - Castillo-Rivas, Jacqueline
AU - Catalá-López, Ferrán
AU - Choi, Jee Young
AU - Christensen, Hanne
AU - Cirillo, Massimo
AU - Cooper, Leslie T Jr.
AU - Criqui, Michael
AU - Cundiff, David
AU - Damasceno, Albertino
AU - Dandona, Lalit
AU - Dandona, Rakhi
AU - Davletov, Kairat
AU - Dharmaratne, Samath
AU - Dorairaj, Prabhakaran
AU - Dubey, Manisha
AU - Ehrenkranz, Rebecca
AU - El Sayed Zaki, Maysaa
AU - Faraon, Emerito Jose A.
AU - Esteghamati, Alireza
AU - Farid, Talha
AU - Farvid, Maryam
AU - Feigin, Valery
AU - Ding, Eric L.
AU - Fowkes, Gerry
AU - Gebrehiwot, Tsegaye
AU - Gillum, Richard
AU - Gold, Audra
AU - Gona, Philimon
AU - Gupta, Rajeev
AU - Habtewold, Tesfa Dejenie
AU - Hafezi-Nejad, Nima
AU - Hailu, Tesfaye
AU - Hailu, Gessessew Bugssa
AU - Hankey, Graeme
AU - Hassen, Hamid Yimam
AU - Abate, Kalkidan Hassen
AU - Havmoeller, Rasmus
AU - Hay, Simon I.
AU - Horino, Masako
AU - Hotez, Peter J.
AU - Jacobsen, Kathryn
AU - James, Spencer
AU - Javanbakht, Mehdi
AU - Jeemon, Panniyammakal
AU - John, Denny
AU - Jonas, Jost
AU - Kalkonde, Yogeshwar
AU - Karimkhani, Chante
AU - Kasaeian, Amir
AU - Khader, Yousef
AU - Khan, Abdur
AU - Khang, Young Ho
AU - Khera, Sahil
AU - Khoja, Abdullah T.
AU - Khubchandani, Jagdish
AU - Kim, Daniel
AU - Kolte, Dhaval
AU - Kosen, Soewarta
AU - Krohn, Kristopher J.
AU - Kumar, G. Anil
AU - Kwan, Gene
AU - Lal, Dharmesh Kumar
AU - Larsson, Anders
AU - Linn, Shai
AU - Lopez, Alan
AU - Lotufo, Paulo A.
AU - El Razek, Hassan Magdy Abd
AU - Malekzadeh, Reza
AU - Mazidi, Mohsen
AU - Meier, Toni
AU - Meles, Kidanu Gebremariam
AU - Mensah, George
AU - Meretoja, Atte
AU - Mezgebe, Haftay
AU - Miller, Ted
AU - Mirrakhimov, Erkin
AU - Mohammed, Shafiu
AU - Moran, Andrew E.
AU - Musa, Kamarul Imran
AU - Narula, Jagat
AU - Neal, Bruce
AU - Ngalesoni, Frida
AU - Nguyen, Grant
AU - Obermeyer, Carla Makhlouf
AU - Owolabi, Mayowa
AU - Patton, George
AU - Pedro, João
AU - Qato, Dima
AU - Qorbani, Mostafa
AU - Rahimi, Kazem
AU - Rai, Rajesh Kumar
AU - Rawaf, Salman
AU - Ribeiro, Antônio
AU - Safiri, Saeid
AU - Salomon, Joshua A.
AU - Santos, Itamar
AU - Santric Milicevic, Milena
AU - Sartorius, Benn
AU - Schutte, Aletta
AU - Sepanlou, Sadaf
AU - Shaikh, Masood Ali
AU - Shin, Min Jeong
AU - Shishehbor, Mehdi
AU - Shore, Hirbo
AU - Silva, Diego Augusto Santos
AU - Sobngwi, Eugene
AU - Stranges, Saverio
AU - Swaminathan, Soumya
AU - Tabarés-Seisdedos, Rafael
AU - Tadele Atnafu, Niguse
AU - Tesfay, Fisaha
AU - Thakur, J. S.
AU - Thrift, Amanda
AU - Topor-Madry, Roman
AU - Truelsen, Thomas
AU - Tyrovolas, Stefanos
AU - Ukwaja, Kingsley Nnanna
AU - Uthman, Olalekan
AU - Vasankari, Tommi
AU - Vlassov, Vasiliy
AU - Vollset, Stein Emil
AU - Wakayo, Tolassa
AU - Watkins, David
AU - Weintraub, Robert
AU - Werdecker, Andrea
AU - Westerman, Ronny
AU - Wiysonge, Charles Shey
AU - Wolfe, Charles
AU - Workicho, Abdulhalik
AU - Xu, Gelin
AU - Yano, Yuichiro
AU - Yip, Paul
AU - Yonemoto, Naohiro
AU - Younis, Mustafa
AU - Yu, Chuanhua
AU - Vos, Theo
AU - Naghavi, Mohsen
AU - Murray, Christopher
PY - 2017/3/8
Y1 - 2017/3/8
N2 - Background: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. Objectives: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. Methods: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Results: In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. Conclusions: CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.
AB - Background: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. Objectives: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. Methods: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Results: In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. Conclusions: CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.
KW - Cause of death
KW - Epidemiology
KW - Global health
UR - http://www.scopus.com/inward/record.url?scp=85019362730&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019362730&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2017.04.052
DO - 10.1016/j.jacc.2017.04.052
M3 - Article
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
ER -