Gliosis specimens contain clonal cytogenetic abnormalities

Cheryl A. Moertel, Richard J. Dahl, Paul G. Stalboerger, David W. Kimmel, Bernd W. Scheithauer, Robert Brian Jenkins

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The relevance of sex chromosome aneusomy and trisomy 7 in neoplastic brain tissue is controversial. For better understanding of the relative importance of these anomalies, we made a conventional cytogenetic study of cells from tissue obtained from patients who underwent partial cerebral resection for a seizure disorder. Each specimen exhibited "gliosis," but none contained histologically identifiable tumor cells. Sixty-six specimens were analyzed by routine cytogenetic methods. Nonclonal abnormalities were observed in 11.6% of the cells (86% of cases) analyzed. In 11 cases, however, simple clonal karyotypes were observed. Of these cases, six involved loss of a Y chromosome and three involved loss of an X chromosome. Among the cases with loss of an X chromosome, two exhibited multiple abnormal clones. One of these cases had trisomy 7 as well as trisomy 18, and another had a supernumerary psu dic(15)(q13). The supernumerary chromosome was constitutional. One patient had possible Klinefelter syndrome. An additional case had a clonal del(10)(q23) that may have resulted from a hereditary fragile site. We conclude that although some of the apparently acquired clonal and nonclonal abnormalities may be due to a consistent in vitro artifact, it is probable that they are present in the brain tissue itself. Whatever the cause, caution should be used in interpretating cytogenetic abnormalities observed in brain tumor specimens.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume67
Issue number1
DOIs
StatePublished - 1993

Fingerprint

Gliosis
Chromosome Aberrations
Trisomy
X Chromosome
Cytogenetics
Klinefelter Syndrome
Sex Chromosomes
Y Chromosome
Brain
Karyotype
Brain Neoplasms
Artifacts
Epilepsy
Clone Cells
Chromosomes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Moertel, C. A., Dahl, R. J., Stalboerger, P. G., Kimmel, D. W., Scheithauer, B. W., & Jenkins, R. B. (1993). Gliosis specimens contain clonal cytogenetic abnormalities. Cancer Genetics and Cytogenetics, 67(1), 21-27. https://doi.org/10.1016/0165-4608(93)90039-O

Gliosis specimens contain clonal cytogenetic abnormalities. / Moertel, Cheryl A.; Dahl, Richard J.; Stalboerger, Paul G.; Kimmel, David W.; Scheithauer, Bernd W.; Jenkins, Robert Brian.

In: Cancer Genetics and Cytogenetics, Vol. 67, No. 1, 1993, p. 21-27.

Research output: Contribution to journalArticle

Moertel, CA, Dahl, RJ, Stalboerger, PG, Kimmel, DW, Scheithauer, BW & Jenkins, RB 1993, 'Gliosis specimens contain clonal cytogenetic abnormalities', Cancer Genetics and Cytogenetics, vol. 67, no. 1, pp. 21-27. https://doi.org/10.1016/0165-4608(93)90039-O
Moertel, Cheryl A. ; Dahl, Richard J. ; Stalboerger, Paul G. ; Kimmel, David W. ; Scheithauer, Bernd W. ; Jenkins, Robert Brian. / Gliosis specimens contain clonal cytogenetic abnormalities. In: Cancer Genetics and Cytogenetics. 1993 ; Vol. 67, No. 1. pp. 21-27.
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