TY - JOUR
T1 - Glioma response assessment
T2 - Classic pitfalls, novel confounders, and emerging imaging tools
AU - Johnson, Derek R.
AU - Guerin, Julie B.
AU - Ruff, Michael W.
AU - Fang, Shanna
AU - Hunt, Christopher H.
AU - Morris, Jonathan M.
AU - Morris, P. Pearse
AU - Kaufmann, Timothy J.
N1 - Publisher Copyright:
© 2019 The Authors. Published by the British Institute of Radiology
PY - 2019
Y1 - 2019
N2 - Neuroimaging plays a pivotal role in the care of patients with infiltrating gliomas, in whom imaging changes are often the first indications of tumor response or progression. Unfortunately, evaluation of glioma response is often not straightforward, even for experienced radiologists. Post-surgical or radiation-related changes may mimic the appearance of disease progression, while medications such as corticosteroids and antiangiogenic agents may mimic tumor response without truly arresting tumor growth or improving patient survival. Immunotherapy response can result in inflammatory changes which manifest as progressively increasing tumor enhancement and edema over months. Many of these pitfalls can be minimized or avoided altogether by the use of modern brain tumor response criteria, while others will require new imaging tools before they can be fully addressed. Advanced MRI methods and novel positron emission tomography (PET) agents are proving important for this purpose, and their role will undoubtedly continue to grow in the future.
AB - Neuroimaging plays a pivotal role in the care of patients with infiltrating gliomas, in whom imaging changes are often the first indications of tumor response or progression. Unfortunately, evaluation of glioma response is often not straightforward, even for experienced radiologists. Post-surgical or radiation-related changes may mimic the appearance of disease progression, while medications such as corticosteroids and antiangiogenic agents may mimic tumor response without truly arresting tumor growth or improving patient survival. Immunotherapy response can result in inflammatory changes which manifest as progressively increasing tumor enhancement and edema over months. Many of these pitfalls can be minimized or avoided altogether by the use of modern brain tumor response criteria, while others will require new imaging tools before they can be fully addressed. Advanced MRI methods and novel positron emission tomography (PET) agents are proving important for this purpose, and their role will undoubtedly continue to grow in the future.
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U2 - 10.1259/bjr.20180730
DO - 10.1259/bjr.20180730
M3 - Article
C2 - 30412421
AN - SCOPUS:85060533700
SN - 0007-1285
VL - 92
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1094
M1 - 20180730
ER -