Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study

Shala G. Berntsson, Ryan T. Merrell, E. Susan Amirian, Georgina N. Armstrong, Daniel H Lachance, Anja Smits, Renke Zhou, Daniel I. Jacobs, Margaret R. Wrensch, Sara H. Olson, Dora Il’yasova, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Joellen Schildkraut, Siegal Sadetzki, Christoffer Johansen, Richard S. Houlston, Robert Brian Jenkins, Jonine L. Bernstein, Rose LaiSanjay Shete, Christopher I. Amos, Melissa L. Bondy, Beatrice S. Melin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalJournal of Neurology
DOIs
StateAccepted/In press - Apr 23 2018

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Glioma
Seizures
etiracetam
Neoplasms
Oligodendroglioma
Astrocytoma
Anticonvulsants
Case-Control Studies
Demography

Keywords

  • Epileptic seizures
  • Glioma-related seizures
  • Observational study (cohort, case–control)
  • Primary brain tumor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Glioma-related seizures in relation to histopathological subtypes : a report from the glioma international case–control study. / Berntsson, Shala G.; Merrell, Ryan T.; Amirian, E. Susan; Armstrong, Georgina N.; Lachance, Daniel H; Smits, Anja; Zhou, Renke; Jacobs, Daniel I.; Wrensch, Margaret R.; Olson, Sara H.; Il’yasova, Dora; Claus, Elizabeth B.; Barnholtz-Sloan, Jill S.; Schildkraut, Joellen; Sadetzki, Siegal; Johansen, Christoffer; Houlston, Richard S.; Jenkins, Robert Brian; Bernstein, Jonine L.; Lai, Rose; Shete, Sanjay; Amos, Christopher I.; Bondy, Melissa L.; Melin, Beatrice S.

In: Journal of Neurology, 23.04.2018, p. 1-11.

Research output: Contribution to journalArticle

Berntsson, SG, Merrell, RT, Amirian, ES, Armstrong, GN, Lachance, DH, Smits, A, Zhou, R, Jacobs, DI, Wrensch, MR, Olson, SH, Il’yasova, D, Claus, EB, Barnholtz-Sloan, JS, Schildkraut, J, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Bernstein, JL, Lai, R, Shete, S, Amos, CI, Bondy, ML & Melin, BS 2018, 'Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study', Journal of Neurology, pp. 1-11. https://doi.org/10.1007/s00415-018-8857-0
Berntsson, Shala G. ; Merrell, Ryan T. ; Amirian, E. Susan ; Armstrong, Georgina N. ; Lachance, Daniel H ; Smits, Anja ; Zhou, Renke ; Jacobs, Daniel I. ; Wrensch, Margaret R. ; Olson, Sara H. ; Il’yasova, Dora ; Claus, Elizabeth B. ; Barnholtz-Sloan, Jill S. ; Schildkraut, Joellen ; Sadetzki, Siegal ; Johansen, Christoffer ; Houlston, Richard S. ; Jenkins, Robert Brian ; Bernstein, Jonine L. ; Lai, Rose ; Shete, Sanjay ; Amos, Christopher I. ; Bondy, Melissa L. ; Melin, Beatrice S. / Glioma-related seizures in relation to histopathological subtypes : a report from the glioma international case–control study. In: Journal of Neurology. 2018 ; pp. 1-11.
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T1 - Glioma-related seizures in relation to histopathological subtypes

T2 - a report from the glioma international case–control study

AU - Berntsson, Shala G.

AU - Merrell, Ryan T.

AU - Amirian, E. Susan

AU - Armstrong, Georgina N.

AU - Lachance, Daniel H

AU - Smits, Anja

AU - Zhou, Renke

AU - Jacobs, Daniel I.

AU - Wrensch, Margaret R.

AU - Olson, Sara H.

AU - Il’yasova, Dora

AU - Claus, Elizabeth B.

AU - Barnholtz-Sloan, Jill S.

AU - Schildkraut, Joellen

AU - Sadetzki, Siegal

AU - Johansen, Christoffer

AU - Houlston, Richard S.

AU - Jenkins, Robert Brian

AU - Bernstein, Jonine L.

AU - Lai, Rose

AU - Shete, Sanjay

AU - Amos, Christopher I.

AU - Bondy, Melissa L.

AU - Melin, Beatrice S.

PY - 2018/4/23

Y1 - 2018/4/23

N2 - Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.

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KW - Observational study (cohort, case–control)

KW - Primary brain tumor

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