Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Patrick Y. Wen, Michael Weller, Eudocia Quant Lee, Brian M. Alexander, Jill S. Barnholtz-Sloan, Floris P. Barthel, Tracy T. Batchelor, Ranjit S. Bindra, Susan M. Chang, E. Antonio Chiocca, Timothy F. Cloughesy, John F. DeGroot, Evanthia Galanis, Mark R. Gilbert, Monika E. Hegi, Craig Horbinski, Raymond Y. Huang, Andrew B. Lassman, Emilie Le Rhun, Michael LimMinesh P. Mehta, Ingo K. Mellinghoff, Giuseppe Minniti, David Nathanson, Michael Platten, Matthias Preusser, Patrick Roth, Marc Sanson, David Schiff, Susan C. Short, Martin J.B. Taphoorn, Joerg Christian Tonn, Jonathan Tsang, Roel G.W. Verhaak, Andreas von Deimling, Wolfgang Wick, Gelareh Zadeh, David A. Reardon, Kenneth D. Aldape, Martin J. van den Bent

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Original languageEnglish (US)
Pages (from-to)1073-1113
Number of pages41
JournalNeuro-oncology
Volume22
Issue number8
DOIs
StatePublished - Aug 17 2020

Keywords

  • clinical trials
  • diagnosis
  • glioblastoma
  • therapy

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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    Wen, P. Y., Weller, M., Lee, E. Q., Alexander, B. M., Barnholtz-Sloan, J. S., Barthel, F. P., Batchelor, T. T., Bindra, R. S., Chang, S. M., Chiocca, E. A., Cloughesy, T. F., DeGroot, J. F., Galanis, E., Gilbert, M. R., Hegi, M. E., Horbinski, C., Huang, R. Y., Lassman, A. B., Le Rhun, E., ... van den Bent, M. J. (2020). Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-oncology, 22(8), 1073-1113. https://doi.org/10.1093/neuonc/noaa106