Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

Baek Vin Lim, Min Chul Shin, Mi Hyeon Jang, Taeck Hyun Lee, Young Pyo Kim, Hyun Bae Kim, Kwang Sik Lee, Hong Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In the present study, the effect of Ginseng radix on cell proliferation in the dentate gyrus of rats with streptozotocin-induced diabetes was investigated via immunohistochemistry. Aqueous extract of Ginseng radix was shown to exert no significant effect on weight in normal rats, while it prevented weight loss in rats with streptozotocin-induced diabetes. Cell proliferation in the dentate gyrus of diabetic rats was increased by Ginseng radix treatment, but it had no effect on cell proliferation in normal rats. These results suggest that Ginseng radix may help in improve the central nervous system complications of diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)1550-1554
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume25
Issue number12
DOIs
StatePublished - Dec 1 2002

Keywords

  • Cell proliferation
  • Dentate gyrus
  • Ginseng radix, streptozotocin-induced diabetes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Lim, B. V., Shin, M. C., Jang, M. H., Lee, T. H., Kim, Y. P., Kim, H. B., Lee, K. S., Kim, H., Kim, E. H., & Kim, C. J. (2002). Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes. Biological and Pharmaceutical Bulletin, 25(12), 1550-1554. https://doi.org/10.1248/bpb.25.1550