GIM, simulation software of meal glucose - Insulin model

Chiara Dalla Man, Davide M. Raimondo, Robert A. Rizza, Claudio Cobelli

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Background: A simulation model of the glucose-insulin system in normal life conditions can be very useful in diabetes research, e.g., testing insulin infusion algorithms and decision support systems and assessing glucose sensor performance and patient and student training. A new meal simulation model has been proposed that incorporates state-of-the-art quantitative knowledge on glucose metabolism and its control by insulin at both organ/tissue and whole-body levels. This article presents the interactive simulation software GIM (glucose insulin model), which implements this model. Methods: The model is implemented in MATLAB, version 7.0.1, and is designed with a windows interface that allows the user to easily simulate a 24-hour daily life of a normal, type 2, or type 1 diabetic subject. A Simulink version is also available. Three meals a day are considered. Both open- and closed-loop controls are available for simulating a type 1 diabetic subject. Results: Software options are described in detail. Case studies are presented to illustrate the potential of the software, e.g., compare a normal subject vs an insulin-resistant subject or open-loop vs closed-loop insulin infusion in type 1 diabetes treatment. Conclusions: User-friendly software that implements a state-of-the-art physiological model of the glucose-insulin system during a meal has been presented. The GIM graphical interface makes its use extremely easy for investigators without specific expertise in modeling.

Original languageEnglish (US)
Pages (from-to)323-330
Number of pages8
JournalJournal of diabetes science and technology
Volume1
Issue number3
StatePublished - May 2007

Fingerprint

Insulin
Glucose
Meals
Software
Medical problems
Physiological models
Glucose sensors
Decision support systems
Type 1 Diabetes Mellitus
Metabolism
MATLAB
Research Personnel
Tissue
Students
Testing
Research

Keywords

  • Artificial pancreas
  • Diabetes
  • Glucose homeostasis
  • Glucose sensors
  • Insulin infusion system
  • Modeling
  • Physiological control

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Bioengineering
  • Biomedical Engineering

Cite this

Dalla Man, C., Raimondo, D. M., Rizza, R. A., & Cobelli, C. (2007). GIM, simulation software of meal glucose - Insulin model. Journal of diabetes science and technology, 1(3), 323-330.

GIM, simulation software of meal glucose - Insulin model. / Dalla Man, Chiara; Raimondo, Davide M.; Rizza, Robert A.; Cobelli, Claudio.

In: Journal of diabetes science and technology, Vol. 1, No. 3, 05.2007, p. 323-330.

Research output: Contribution to journalArticle

Dalla Man, C, Raimondo, DM, Rizza, RA & Cobelli, C 2007, 'GIM, simulation software of meal glucose - Insulin model', Journal of diabetes science and technology, vol. 1, no. 3, pp. 323-330.
Dalla Man C, Raimondo DM, Rizza RA, Cobelli C. GIM, simulation software of meal glucose - Insulin model. Journal of diabetes science and technology. 2007 May;1(3):323-330.
Dalla Man, Chiara ; Raimondo, Davide M. ; Rizza, Robert A. ; Cobelli, Claudio. / GIM, simulation software of meal glucose - Insulin model. In: Journal of diabetes science and technology. 2007 ; Vol. 1, No. 3. pp. 323-330.
@article{8f14b85556d740d49cc5edf1f90da32b,
title = "GIM, simulation software of meal glucose - Insulin model",
abstract = "Background: A simulation model of the glucose-insulin system in normal life conditions can be very useful in diabetes research, e.g., testing insulin infusion algorithms and decision support systems and assessing glucose sensor performance and patient and student training. A new meal simulation model has been proposed that incorporates state-of-the-art quantitative knowledge on glucose metabolism and its control by insulin at both organ/tissue and whole-body levels. This article presents the interactive simulation software GIM (glucose insulin model), which implements this model. Methods: The model is implemented in MATLAB, version 7.0.1, and is designed with a windows interface that allows the user to easily simulate a 24-hour daily life of a normal, type 2, or type 1 diabetic subject. A Simulink version is also available. Three meals a day are considered. Both open- and closed-loop controls are available for simulating a type 1 diabetic subject. Results: Software options are described in detail. Case studies are presented to illustrate the potential of the software, e.g., compare a normal subject vs an insulin-resistant subject or open-loop vs closed-loop insulin infusion in type 1 diabetes treatment. Conclusions: User-friendly software that implements a state-of-the-art physiological model of the glucose-insulin system during a meal has been presented. The GIM graphical interface makes its use extremely easy for investigators without specific expertise in modeling.",
keywords = "Artificial pancreas, Diabetes, Glucose homeostasis, Glucose sensors, Insulin infusion system, Modeling, Physiological control",
author = "{Dalla Man}, Chiara and Raimondo, {Davide M.} and Rizza, {Robert A.} and Claudio Cobelli",
year = "2007",
month = "5",
language = "English (US)",
volume = "1",
pages = "323--330",
journal = "Journal of diabetes science and technology",
issn = "1932-2968",
publisher = "Diabetes Technology Society",
number = "3",

}

TY - JOUR

T1 - GIM, simulation software of meal glucose - Insulin model

AU - Dalla Man, Chiara

AU - Raimondo, Davide M.

AU - Rizza, Robert A.

AU - Cobelli, Claudio

PY - 2007/5

Y1 - 2007/5

N2 - Background: A simulation model of the glucose-insulin system in normal life conditions can be very useful in diabetes research, e.g., testing insulin infusion algorithms and decision support systems and assessing glucose sensor performance and patient and student training. A new meal simulation model has been proposed that incorporates state-of-the-art quantitative knowledge on glucose metabolism and its control by insulin at both organ/tissue and whole-body levels. This article presents the interactive simulation software GIM (glucose insulin model), which implements this model. Methods: The model is implemented in MATLAB, version 7.0.1, and is designed with a windows interface that allows the user to easily simulate a 24-hour daily life of a normal, type 2, or type 1 diabetic subject. A Simulink version is also available. Three meals a day are considered. Both open- and closed-loop controls are available for simulating a type 1 diabetic subject. Results: Software options are described in detail. Case studies are presented to illustrate the potential of the software, e.g., compare a normal subject vs an insulin-resistant subject or open-loop vs closed-loop insulin infusion in type 1 diabetes treatment. Conclusions: User-friendly software that implements a state-of-the-art physiological model of the glucose-insulin system during a meal has been presented. The GIM graphical interface makes its use extremely easy for investigators without specific expertise in modeling.

AB - Background: A simulation model of the glucose-insulin system in normal life conditions can be very useful in diabetes research, e.g., testing insulin infusion algorithms and decision support systems and assessing glucose sensor performance and patient and student training. A new meal simulation model has been proposed that incorporates state-of-the-art quantitative knowledge on glucose metabolism and its control by insulin at both organ/tissue and whole-body levels. This article presents the interactive simulation software GIM (glucose insulin model), which implements this model. Methods: The model is implemented in MATLAB, version 7.0.1, and is designed with a windows interface that allows the user to easily simulate a 24-hour daily life of a normal, type 2, or type 1 diabetic subject. A Simulink version is also available. Three meals a day are considered. Both open- and closed-loop controls are available for simulating a type 1 diabetic subject. Results: Software options are described in detail. Case studies are presented to illustrate the potential of the software, e.g., compare a normal subject vs an insulin-resistant subject or open-loop vs closed-loop insulin infusion in type 1 diabetes treatment. Conclusions: User-friendly software that implements a state-of-the-art physiological model of the glucose-insulin system during a meal has been presented. The GIM graphical interface makes its use extremely easy for investigators without specific expertise in modeling.

KW - Artificial pancreas

KW - Diabetes

KW - Glucose homeostasis

KW - Glucose sensors

KW - Insulin infusion system

KW - Modeling

KW - Physiological control

UR - http://www.scopus.com/inward/record.url?scp=84885716740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885716740&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84885716740

VL - 1

SP - 323

EP - 330

JO - Journal of diabetes science and technology

JF - Journal of diabetes science and technology

SN - 1932-2968

IS - 3

ER -