Giant sucking sound: Can physiology fill the intellectual void left by the reductionists?

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Molecular reductionism has so far failed to deliver the broad-based therapeutic insights that were initially hoped for. This form of reductionism is now being replaced by so-called "systems biology." This is a nebulously defined approach and/or discipline, with some versions of it relying excessively on hypothesis-neutral approaches and only minimally informed by key physiological concepts such as homeostasis and regulation. In this context, physiology is uniquely positioned to continue to provide impressive levels of both biological and therapeutic insight by using hypothesis-driven "classical" approaches and concepts to help frame what might be described as the "pieces of the puzzle" that emerge from molecular reductionism. The strength of physiology as a "bridge" between reductionism and epidemiology, along with its unparalleled ability to generate therapeutic insights and opportunities justifies increased attention and emphasis on our discipline into the future. Arguments relevant to this set of assertions are advanced and this paper, which was based on the 2011 Adolph Lecture, represents an effort to fill the intellectual void left by reductionism and improve scientific progress.

Original languageEnglish (US)
Pages (from-to)335-342
Number of pages8
JournalJournal of Applied Physiology
Volume111
Issue number2
DOIs
StatePublished - Aug 2011

Fingerprint

Physiological Phenomena
Systems Biology
Epidemiology
Homeostasis
Therapeutics

Keywords

  • Homeostasis
  • Integrative
  • Regulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Giant sucking sound : Can physiology fill the intellectual void left by the reductionists? / Joyner, Michael Joseph.

In: Journal of Applied Physiology, Vol. 111, No. 2, 08.2011, p. 335-342.

Research output: Contribution to journalArticle

@article{c0c5823846da4de681f9c4fa3a1ebd97,
title = "Giant sucking sound: Can physiology fill the intellectual void left by the reductionists?",
abstract = "Molecular reductionism has so far failed to deliver the broad-based therapeutic insights that were initially hoped for. This form of reductionism is now being replaced by so-called {"}systems biology.{"} This is a nebulously defined approach and/or discipline, with some versions of it relying excessively on hypothesis-neutral approaches and only minimally informed by key physiological concepts such as homeostasis and regulation. In this context, physiology is uniquely positioned to continue to provide impressive levels of both biological and therapeutic insight by using hypothesis-driven {"}classical{"} approaches and concepts to help frame what might be described as the {"}pieces of the puzzle{"} that emerge from molecular reductionism. The strength of physiology as a {"}bridge{"} between reductionism and epidemiology, along with its unparalleled ability to generate therapeutic insights and opportunities justifies increased attention and emphasis on our discipline into the future. Arguments relevant to this set of assertions are advanced and this paper, which was based on the 2011 Adolph Lecture, represents an effort to fill the intellectual void left by reductionism and improve scientific progress.",
keywords = "Homeostasis, Integrative, Regulation",
author = "Joyner, {Michael Joseph}",
year = "2011",
month = "8",
doi = "10.1152/japplphysiol.00565.2011",
language = "English (US)",
volume = "111",
pages = "335--342",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Giant sucking sound

T2 - Can physiology fill the intellectual void left by the reductionists?

AU - Joyner, Michael Joseph

PY - 2011/8

Y1 - 2011/8

N2 - Molecular reductionism has so far failed to deliver the broad-based therapeutic insights that were initially hoped for. This form of reductionism is now being replaced by so-called "systems biology." This is a nebulously defined approach and/or discipline, with some versions of it relying excessively on hypothesis-neutral approaches and only minimally informed by key physiological concepts such as homeostasis and regulation. In this context, physiology is uniquely positioned to continue to provide impressive levels of both biological and therapeutic insight by using hypothesis-driven "classical" approaches and concepts to help frame what might be described as the "pieces of the puzzle" that emerge from molecular reductionism. The strength of physiology as a "bridge" between reductionism and epidemiology, along with its unparalleled ability to generate therapeutic insights and opportunities justifies increased attention and emphasis on our discipline into the future. Arguments relevant to this set of assertions are advanced and this paper, which was based on the 2011 Adolph Lecture, represents an effort to fill the intellectual void left by reductionism and improve scientific progress.

AB - Molecular reductionism has so far failed to deliver the broad-based therapeutic insights that were initially hoped for. This form of reductionism is now being replaced by so-called "systems biology." This is a nebulously defined approach and/or discipline, with some versions of it relying excessively on hypothesis-neutral approaches and only minimally informed by key physiological concepts such as homeostasis and regulation. In this context, physiology is uniquely positioned to continue to provide impressive levels of both biological and therapeutic insight by using hypothesis-driven "classical" approaches and concepts to help frame what might be described as the "pieces of the puzzle" that emerge from molecular reductionism. The strength of physiology as a "bridge" between reductionism and epidemiology, along with its unparalleled ability to generate therapeutic insights and opportunities justifies increased attention and emphasis on our discipline into the future. Arguments relevant to this set of assertions are advanced and this paper, which was based on the 2011 Adolph Lecture, represents an effort to fill the intellectual void left by reductionism and improve scientific progress.

KW - Homeostasis

KW - Integrative

KW - Regulation

UR - http://www.scopus.com/inward/record.url?scp=80051654452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051654452&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00565.2011

DO - 10.1152/japplphysiol.00565.2011

M3 - Article

C2 - 21636568

AN - SCOPUS:80051654452

VL - 111

SP - 335

EP - 342

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -