Abstract
Recent studies have suggested that a deficiency of α1-antitrypsin may be a genetic risk factor for the development of intracranial aneurysms and arterial fibromuscular dysplasia. The authors report a 16-year-old girl with a history of lung disease who suffered a cerebral hemorrhage due to the rupture of a giant intracranial aneurysm arising from the middle cerebral artery. This fusiform aneurysm was associated with fibromuscular dysplasia of the intimal type. She was found to have an unusual α1-antitrypsin deficiency (PiMP phenotype). This case provides further evidence of an underlying arteriopathy in α1-antitrypsin deficiency.
Original language | English (US) |
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Pages (from-to) | 503-506 |
Number of pages | 4 |
Journal | Journal of neurosurgery |
Volume | 85 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1996 |
Keywords
- cerebral aneurysm
- fibromuscular dysplasia
- subarachnoid hemorrhage
- α-antitrypsin deficiency
ASJC Scopus subject areas
- Surgery
- Clinical Neurology