Giant cell cancer of the lung: Diagnosis and treatment monitoring with PET/CT

Mary E. Miller, Alison M. Coates, Maqbool A. Halepota, Eric R. Kovalsky, Susan Passalaqua, Michael Gotway, Ronald L. Korn

Research output: Contribution to journalShort survey

Abstract

Bronchogenic carcinoma is the most common primary tumor affecting lung. Four main histopathological subtypes of bronchogenic carcinoma are recognized, and several variants of these histopathological subtypes are also known. Among the 4 main histopathological subtypes of bronchogenic carcinoma, large cell carcinoma is the least commonly encountered. Rarer still is a subtype of large cell carcinoma known as giant cell carcinoma. We report the detection and characterization of pulmonary giant cell carcinoma using 18F-fluoro-2- deoxyglucose positron emission tomography/computed tomography (FDG-PET-CT). FDG-PET-CT showed intense hypermetabolic activity within the primary lesion, which subsequently decreased, and then resolved following antineoplastic therapy. FDG-PET-CT also allowed detection of sites of recurrence of the tumor following cessation of therapy. This report highlights the usefulness of FDG-PET-CT for the detection of an unusual thoracic neoplasm as well as the ability of FDG-PET-CT for assessing response to therapy.

Original languageEnglish (US)
Pages (from-to)106-108
Number of pages3
JournalClinical Pulmonary Medicine
Volume17
Issue number2
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Deoxyglucose
Giant Cells
Lung Neoplasms
Bronchogenic Carcinoma
Giant Cell Carcinoma
Large Cell Carcinoma
Thoracic Neoplasms
Lung
Antineoplastic Agents
Neoplasms
Therapeutics
Positron Emission Tomography Computed Tomography
Recurrence

Keywords

  • Computed tomography
  • Giant cell carcinoma of lung
  • Hypermetabolic
  • Large cell carcinoma
  • Non-small-cell carcinoma
  • Positron emission tomography
  • Pulmonary neoplasia
  • Response to therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Miller, M. E., Coates, A. M., Halepota, M. A., Kovalsky, E. R., Passalaqua, S., Gotway, M., & Korn, R. L. (2010). Giant cell cancer of the lung: Diagnosis and treatment monitoring with PET/CT. Clinical Pulmonary Medicine, 17(2), 106-108. https://doi.org/10.1097/CPM.0b013e3181d139ab

Giant cell cancer of the lung : Diagnosis and treatment monitoring with PET/CT. / Miller, Mary E.; Coates, Alison M.; Halepota, Maqbool A.; Kovalsky, Eric R.; Passalaqua, Susan; Gotway, Michael; Korn, Ronald L.

In: Clinical Pulmonary Medicine, Vol. 17, No. 2, 03.2010, p. 106-108.

Research output: Contribution to journalShort survey

Miller, ME, Coates, AM, Halepota, MA, Kovalsky, ER, Passalaqua, S, Gotway, M & Korn, RL 2010, 'Giant cell cancer of the lung: Diagnosis and treatment monitoring with PET/CT', Clinical Pulmonary Medicine, vol. 17, no. 2, pp. 106-108. https://doi.org/10.1097/CPM.0b013e3181d139ab
Miller, Mary E. ; Coates, Alison M. ; Halepota, Maqbool A. ; Kovalsky, Eric R. ; Passalaqua, Susan ; Gotway, Michael ; Korn, Ronald L. / Giant cell cancer of the lung : Diagnosis and treatment monitoring with PET/CT. In: Clinical Pulmonary Medicine. 2010 ; Vol. 17, No. 2. pp. 106-108.
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