Giant cell cancer of the lung: Diagnosis and treatment monitoring with PET/CT

Mary E. Miller; Alison M. Coates; Maqbool A. Halepota; Eric R. Kovalsky; Susan Passalaqua; Michael B. Gotway; Ronald L. Korn

doi:10.1097/CPM.0b013e3181d139ab

Giant cell cancer of the lung: Diagnosis and treatment monitoring with PET/CT

Mary E. Miller, Alison M. Coates, Maqbool A. Halepota, Eric R. Kovalsky, Susan Passalaqua, Michael B. Gotway, Ronald L. Korn

Diagnostic Radiology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Bronchogenic carcinoma is the most common primary tumor affecting lung. Four main histopathological subtypes of bronchogenic carcinoma are recognized, and several variants of these histopathological subtypes are also known. Among the 4 main histopathological subtypes of bronchogenic carcinoma, large cell carcinoma is the least commonly encountered. Rarer still is a subtype of large cell carcinoma known as giant cell carcinoma. We report the detection and characterization of pulmonary giant cell carcinoma using 18F-fluoro-2- deoxyglucose positron emission tomography/computed tomography (FDG-PET-CT). FDG-PET-CT showed intense hypermetabolic activity within the primary lesion, which subsequently decreased, and then resolved following antineoplastic therapy. FDG-PET-CT also allowed detection of sites of recurrence of the tumor following cessation of therapy. This report highlights the usefulness of FDG-PET-CT for the detection of an unusual thoracic neoplasm as well as the ability of FDG-PET-CT for assessing response to therapy.

Original language	English (US)
Pages (from-to)	106-108
Number of pages	3
Journal	Clinical Pulmonary Medicine
Volume	17
Issue number	2
DOIs	https://doi.org/10.1097/CPM.0b013e3181d139ab
State	Published - Mar 2010

Keywords

Computed tomography
Giant cell carcinoma of lung
Hypermetabolic
Large cell carcinoma
Non-small-cell carcinoma
Positron emission tomography
Pulmonary neoplasia
Response to therapy

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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title = "Giant cell cancer of the lung: Diagnosis and treatment monitoring with PET/CT",

abstract = "Bronchogenic carcinoma is the most common primary tumor affecting lung. Four main histopathological subtypes of bronchogenic carcinoma are recognized, and several variants of these histopathological subtypes are also known. Among the 4 main histopathological subtypes of bronchogenic carcinoma, large cell carcinoma is the least commonly encountered. Rarer still is a subtype of large cell carcinoma known as giant cell carcinoma. We report the detection and characterization of pulmonary giant cell carcinoma using 18F-fluoro-2- deoxyglucose positron emission tomography/computed tomography (FDG-PET-CT). FDG-PET-CT showed intense hypermetabolic activity within the primary lesion, which subsequently decreased, and then resolved following antineoplastic therapy. FDG-PET-CT also allowed detection of sites of recurrence of the tumor following cessation of therapy. This report highlights the usefulness of FDG-PET-CT for the detection of an unusual thoracic neoplasm as well as the ability of FDG-PET-CT for assessing response to therapy.",

keywords = "Computed tomography, Giant cell carcinoma of lung, Hypermetabolic, Large cell carcinoma, Non-small-cell carcinoma, Positron emission tomography, Pulmonary neoplasia, Response to therapy",

author = "Miller, {Mary E.} and Coates, {Alison M.} and Halepota, {Maqbool A.} and Kovalsky, {Eric R.} and Susan Passalaqua and Gotway, {Michael B.} and Korn, {Ronald L.}",

year = "2010",

month = mar,

doi = "10.1097/CPM.0b013e3181d139ab",

language = "English (US)",

volume = "17",

pages = "106--108",

journal = "Clinical Pulmonary Medicine",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Giant cell cancer of the lung

T2 - Diagnosis and treatment monitoring with PET/CT

AU - Miller, Mary E.

AU - Coates, Alison M.

AU - Halepota, Maqbool A.

AU - Kovalsky, Eric R.

AU - Passalaqua, Susan

AU - Gotway, Michael B.

AU - Korn, Ronald L.

PY - 2010/3

Y1 - 2010/3

N2 - Bronchogenic carcinoma is the most common primary tumor affecting lung. Four main histopathological subtypes of bronchogenic carcinoma are recognized, and several variants of these histopathological subtypes are also known. Among the 4 main histopathological subtypes of bronchogenic carcinoma, large cell carcinoma is the least commonly encountered. Rarer still is a subtype of large cell carcinoma known as giant cell carcinoma. We report the detection and characterization of pulmonary giant cell carcinoma using 18F-fluoro-2- deoxyglucose positron emission tomography/computed tomography (FDG-PET-CT). FDG-PET-CT showed intense hypermetabolic activity within the primary lesion, which subsequently decreased, and then resolved following antineoplastic therapy. FDG-PET-CT also allowed detection of sites of recurrence of the tumor following cessation of therapy. This report highlights the usefulness of FDG-PET-CT for the detection of an unusual thoracic neoplasm as well as the ability of FDG-PET-CT for assessing response to therapy.

AB - Bronchogenic carcinoma is the most common primary tumor affecting lung. Four main histopathological subtypes of bronchogenic carcinoma are recognized, and several variants of these histopathological subtypes are also known. Among the 4 main histopathological subtypes of bronchogenic carcinoma, large cell carcinoma is the least commonly encountered. Rarer still is a subtype of large cell carcinoma known as giant cell carcinoma. We report the detection and characterization of pulmonary giant cell carcinoma using 18F-fluoro-2- deoxyglucose positron emission tomography/computed tomography (FDG-PET-CT). FDG-PET-CT showed intense hypermetabolic activity within the primary lesion, which subsequently decreased, and then resolved following antineoplastic therapy. FDG-PET-CT also allowed detection of sites of recurrence of the tumor following cessation of therapy. This report highlights the usefulness of FDG-PET-CT for the detection of an unusual thoracic neoplasm as well as the ability of FDG-PET-CT for assessing response to therapy.

KW - Computed tomography

KW - Giant cell carcinoma of lung

KW - Hypermetabolic

KW - Large cell carcinoma

KW - Non-small-cell carcinoma

KW - Positron emission tomography

KW - Pulmonary neoplasia

KW - Response to therapy

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DO - 10.1097/CPM.0b013e3181d139ab

M3 - Short survey

AN - SCOPUS:77952385520

SN - 1068-0640

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JO - Clinical Pulmonary Medicine

JF - Clinical Pulmonary Medicine

IS - 2

ER -

Giant cell cancer of the lung: Diagnosis and treatment monitoring with PET/CT

Abstract

Keywords

ASJC Scopus subject areas

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