GFAP IgG associated inflammatory polyneuropathy

Pritikanta Paul, Andrew McKeon, Sean J. Pittock, Christopher J. Klein, Shailee Shah, Michel Toledano, John R. Mills, Divyanshu Dubey

Research output: Contribution to journalArticle

Abstract

Background: GFAP (glial fibrillary acidic protein)-IgG is predominantly associated with meningoencephalomyelitis, and neuropathy presentations are rare. Methods: We reviewed clinical, electrodiagnostic and histopathological presentations of GFAP-IgG associated peripheral neuropathy. Results: We identified six cases, five of whom had peripheral neuropathy as the initial presentation. Acute/subacute polyradicluoneuropathy or proximal nerve involvement was a common presentation. Three had demyelinating neuropathies on electrophysiological studies. Nerve biopsies (n = 2) demonstrated T-cell predominant perivascular inflammatory collections, and all patients with clinical follow up responded favorably to immunotherapy. Conclusion: GFAP neuropathy represents a potentially treatable immune-mediated neuropathy and can occur with or without co-existing meningoencephalomyelitis.

Original languageEnglish (US)
Article number577233
JournalJournal of neuroimmunology
Volume343
DOIs
StatePublished - Jun 15 2020

Keywords

  • Antibodies
  • GFAP
  • Peripheral neuropathy
  • Polyradiculoneuropathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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