Gestational age and neonatal brain microstructure in term born infants

A birth cohort study

Birit F P Broekman, Changqing Wang, Yue Li, Anne Rifkin-Graboi, Seang Mei Saw, Yap Seng Chong, Kenneth Kwek, Peter D. Gluckman, Marielle V. Fortier, Michael J. Meaney, Anqi Qiu, Allan Sheppard, Amutha Chinnadurai, Anne Ferguson-Smith, Anne Eng Neo Goh, Arijit Biswas, Audrey Chia, Birit Broekman, Borys Shuter, Shirong Cai & 69 others Chan Yiong Huak, Cheryl Ngo, Chiang Wen Chin, Chai Kiat Chng, Shang Chee Chong, Christiani Jeyakumar Henry, Mei Chien Chua, Cornelia Yin Ing Chee, Yam Thiam Daniel Goh, Dennis Bier, Chun Ming Ding, Doris Fok, Eric Andrew Finkelstein, Fabian Kok Peng Yap, George Seow Heong Yeo, Wee Meng Han, Helen Chen, Helena Marieke Verkooijen, Hugo P S Van Bever, Hazel Inskip, Iliana Magiati, Inez Bik Yun Wong, Jeevesh Kapur, Jenny L. Richmond, Jerry Kok Yen Chan, Johanna Holbrook, Joshua J. Gooley, Keith M. Godfrey, Krishnamoorthy Niduvaje, Bee Wah Lee, Yung Seng Lee, Leher Singh, Sok Bee Lim, Lourdes Mary Daniel, Seong Feei Loh, Yen Ling Low, Pei Chi Lynette Shek, Marielle Fortier, Mark Hanson, Mary Foong Fong Chong, Michael H. Heymann, Michael Meaney, Mikael Hartman, Mya Thway Tint, Susan Morton, Wei Wei Pang, Peter Gluckman, Pratibha Agarwal, Boon Long Quah, Rob M. Van Dam, David Stringer, Salome Antonette Rebello, Wing Chee So, So Wing Chee, E. Soh Shu, Chin Ying Hsu, Lin Lin Su, Jenny Tang, Kok Hian Tan, Soek Hui Tan, Oon Hoe Teoh, Terry Tong Yoke Yin, Thomas Walczyk, Victor Samuel Rajadurai, Walter Stunkel, Sudhakar K Venkatesh, Wong Peng Cheang, P. C. Wong, Sudhakar K. Venkatesh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Understanding healthy brain development in utero is crucial in order to detect abnormal developmental trajectories due to developmental disorders. However, in most studies neuroimaging was done after a significant postnatal period, and in those studies that performed neuroimaging on fetuses, the quality of data has been affected due to complications of scanning during pregnancy. To understand healthy brain development between 37-41 weeks of gestational age, our study assessed the in utero growth of the brain in healthy term born babies with DTI scanning soon after birth.

Methods: A cohort of 93 infants recruited from maternity hospitals in Singapore underwent diffusion tensor imaging between 5 to 17 days after birth. We did a cross-sectional examination of white matter microstructure of the brain among healthy term infants as a function of gestational age via voxel-based analysis on fractional anisotropy.

Results: Greater gestational age at birth in term infants was associated with larger fractional anisotropy values in early developing brain regions, when corrected for age at scan. Specifically, it was associated with a cluster located at the corpus callosum (corrected p<0.001), as well as another cluster spanning areas of the anterior corona radiata, anterior limb of internal capsule, and external capsule (corrected p<0.001).

Conclusions: Our findings show variation in brain maturation associated with gestational age amongst 'term' infants, with increased brain maturation when born with a relatively higher gestational age in comparison to those infants born with a relatively younger gestational age. Future studies should explore if these differences in brain maturation between 37 and 41 weeks of gestational age will persist over time due to development outside the womb.

Original languageEnglish (US)
Article numbere115229
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 23 2014
Externally publishedYes

Fingerprint

gestational age
cohort studies
microstructure
Gestational Age
Brain
Cohort Studies
Parturition
brain
Microstructure
Neuroimaging
Anisotropy
Capsules
Diffusion tensor imaging
Scanning
Internal Capsule
Maternity Hospitals
Diffusion Tensor Imaging
Corpus Callosum
Singapore
postpartum period

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Broekman, B. F. P., Wang, C., Li, Y., Rifkin-Graboi, A., Saw, S. M., Chong, Y. S., ... Venkatesh, S. K. (2014). Gestational age and neonatal brain microstructure in term born infants: A birth cohort study. PLoS One, 9(12), [e115229]. https://doi.org/10.1371/journal.pone.0115229

Gestational age and neonatal brain microstructure in term born infants : A birth cohort study. / Broekman, Birit F P; Wang, Changqing; Li, Yue; Rifkin-Graboi, Anne; Saw, Seang Mei; Chong, Yap Seng; Kwek, Kenneth; Gluckman, Peter D.; Fortier, Marielle V.; Meaney, Michael J.; Qiu, Anqi; Sheppard, Allan; Chinnadurai, Amutha; Ferguson-Smith, Anne; Goh, Anne Eng Neo; Biswas, Arijit; Chia, Audrey; Broekman, Birit; Shuter, Borys; Cai, Shirong; Huak, Chan Yiong; Ngo, Cheryl; Chin, Chiang Wen; Chng, Chai Kiat; Chong, Shang Chee; Henry, Christiani Jeyakumar; Chua, Mei Chien; Chee, Cornelia Yin Ing; Goh, Yam Thiam Daniel; Bier, Dennis; Ding, Chun Ming; Fok, Doris; Finkelstein, Eric Andrew; Yap, Fabian Kok Peng; Yeo, George Seow Heong; Han, Wee Meng; Chen, Helen; Verkooijen, Helena Marieke; Van Bever, Hugo P S; Inskip, Hazel; Magiati, Iliana; Wong, Inez Bik Yun; Kapur, Jeevesh; Richmond, Jenny L.; Chan, Jerry Kok Yen; Holbrook, Johanna; Gooley, Joshua J.; Godfrey, Keith M.; Niduvaje, Krishnamoorthy; Lee, Bee Wah; Lee, Yung Seng; Singh, Leher; Lim, Sok Bee; Daniel, Lourdes Mary; Loh, Seong Feei; Low, Yen Ling; Shek, Pei Chi Lynette; Fortier, Marielle; Hanson, Mark; Chong, Mary Foong Fong; Heymann, Michael H.; Meaney, Michael; Hartman, Mikael; Tint, Mya Thway; Morton, Susan; Pang, Wei Wei; Gluckman, Peter; Agarwal, Pratibha; Quah, Boon Long; Van Dam, Rob M.; Stringer, David; Rebello, Salome Antonette; So, Wing Chee; Chee, So Wing; Soh Shu, E.; Hsu, Chin Ying; Su, Lin Lin; Tang, Jenny; Tan, Kok Hian; Tan, Soek Hui; Teoh, Oon Hoe; Yin, Terry Tong Yoke; Walczyk, Thomas; Rajadurai, Victor Samuel; Stunkel, Walter; Venkatesh, Sudhakar K; Cheang, Wong Peng; Wong, P. C.; Venkatesh, Sudhakar K.

In: PLoS One, Vol. 9, No. 12, e115229, 23.12.2014.

Research output: Contribution to journalArticle

Broekman, BFP, Wang, C, Li, Y, Rifkin-Graboi, A, Saw, SM, Chong, YS, Kwek, K, Gluckman, PD, Fortier, MV, Meaney, MJ, Qiu, A, Sheppard, A, Chinnadurai, A, Ferguson-Smith, A, Goh, AEN, Biswas, A, Chia, A, Broekman, B, Shuter, B, Cai, S, Huak, CY, Ngo, C, Chin, CW, Chng, CK, Chong, SC, Henry, CJ, Chua, MC, Chee, CYI, Goh, YTD, Bier, D, Ding, CM, Fok, D, Finkelstein, EA, Yap, FKP, Yeo, GSH, Han, WM, Chen, H, Verkooijen, HM, Van Bever, HPS, Inskip, H, Magiati, I, Wong, IBY, Kapur, J, Richmond, JL, Chan, JKY, Holbrook, J, Gooley, JJ, Godfrey, KM, Niduvaje, K, Lee, BW, Lee, YS, Singh, L, Lim, SB, Daniel, LM, Loh, SF, Low, YL, Shek, PCL, Fortier, M, Hanson, M, Chong, MFF, Heymann, MH, Meaney, M, Hartman, M, Tint, MT, Morton, S, Pang, WW, Gluckman, P, Agarwal, P, Quah, BL, Van Dam, RM, Stringer, D, Rebello, SA, So, WC, Chee, SW, Soh Shu, E, Hsu, CY, Su, LL, Tang, J, Tan, KH, Tan, SH, Teoh, OH, Yin, TTY, Walczyk, T, Rajadurai, VS, Stunkel, W, Venkatesh, SK, Cheang, WP, Wong, PC & Venkatesh, SK 2014, 'Gestational age and neonatal brain microstructure in term born infants: A birth cohort study', PLoS One, vol. 9, no. 12, e115229. https://doi.org/10.1371/journal.pone.0115229
Broekman BFP, Wang C, Li Y, Rifkin-Graboi A, Saw SM, Chong YS et al. Gestational age and neonatal brain microstructure in term born infants: A birth cohort study. PLoS One. 2014 Dec 23;9(12). e115229. https://doi.org/10.1371/journal.pone.0115229
Broekman, Birit F P ; Wang, Changqing ; Li, Yue ; Rifkin-Graboi, Anne ; Saw, Seang Mei ; Chong, Yap Seng ; Kwek, Kenneth ; Gluckman, Peter D. ; Fortier, Marielle V. ; Meaney, Michael J. ; Qiu, Anqi ; Sheppard, Allan ; Chinnadurai, Amutha ; Ferguson-Smith, Anne ; Goh, Anne Eng Neo ; Biswas, Arijit ; Chia, Audrey ; Broekman, Birit ; Shuter, Borys ; Cai, Shirong ; Huak, Chan Yiong ; Ngo, Cheryl ; Chin, Chiang Wen ; Chng, Chai Kiat ; Chong, Shang Chee ; Henry, Christiani Jeyakumar ; Chua, Mei Chien ; Chee, Cornelia Yin Ing ; Goh, Yam Thiam Daniel ; Bier, Dennis ; Ding, Chun Ming ; Fok, Doris ; Finkelstein, Eric Andrew ; Yap, Fabian Kok Peng ; Yeo, George Seow Heong ; Han, Wee Meng ; Chen, Helen ; Verkooijen, Helena Marieke ; Van Bever, Hugo P S ; Inskip, Hazel ; Magiati, Iliana ; Wong, Inez Bik Yun ; Kapur, Jeevesh ; Richmond, Jenny L. ; Chan, Jerry Kok Yen ; Holbrook, Johanna ; Gooley, Joshua J. ; Godfrey, Keith M. ; Niduvaje, Krishnamoorthy ; Lee, Bee Wah ; Lee, Yung Seng ; Singh, Leher ; Lim, Sok Bee ; Daniel, Lourdes Mary ; Loh, Seong Feei ; Low, Yen Ling ; Shek, Pei Chi Lynette ; Fortier, Marielle ; Hanson, Mark ; Chong, Mary Foong Fong ; Heymann, Michael H. ; Meaney, Michael ; Hartman, Mikael ; Tint, Mya Thway ; Morton, Susan ; Pang, Wei Wei ; Gluckman, Peter ; Agarwal, Pratibha ; Quah, Boon Long ; Van Dam, Rob M. ; Stringer, David ; Rebello, Salome Antonette ; So, Wing Chee ; Chee, So Wing ; Soh Shu, E. ; Hsu, Chin Ying ; Su, Lin Lin ; Tang, Jenny ; Tan, Kok Hian ; Tan, Soek Hui ; Teoh, Oon Hoe ; Yin, Terry Tong Yoke ; Walczyk, Thomas ; Rajadurai, Victor Samuel ; Stunkel, Walter ; Venkatesh, Sudhakar K ; Cheang, Wong Peng ; Wong, P. C. ; Venkatesh, Sudhakar K. / Gestational age and neonatal brain microstructure in term born infants : A birth cohort study. In: PLoS One. 2014 ; Vol. 9, No. 12.
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abstract = "Objective: Understanding healthy brain development in utero is crucial in order to detect abnormal developmental trajectories due to developmental disorders. However, in most studies neuroimaging was done after a significant postnatal period, and in those studies that performed neuroimaging on fetuses, the quality of data has been affected due to complications of scanning during pregnancy. To understand healthy brain development between 37-41 weeks of gestational age, our study assessed the in utero growth of the brain in healthy term born babies with DTI scanning soon after birth.Methods: A cohort of 93 infants recruited from maternity hospitals in Singapore underwent diffusion tensor imaging between 5 to 17 days after birth. We did a cross-sectional examination of white matter microstructure of the brain among healthy term infants as a function of gestational age via voxel-based analysis on fractional anisotropy.Results: Greater gestational age at birth in term infants was associated with larger fractional anisotropy values in early developing brain regions, when corrected for age at scan. Specifically, it was associated with a cluster located at the corpus callosum (corrected p<0.001), as well as another cluster spanning areas of the anterior corona radiata, anterior limb of internal capsule, and external capsule (corrected p<0.001).Conclusions: Our findings show variation in brain maturation associated with gestational age amongst 'term' infants, with increased brain maturation when born with a relatively higher gestational age in comparison to those infants born with a relatively younger gestational age. Future studies should explore if these differences in brain maturation between 37 and 41 weeks of gestational age will persist over time due to development outside the womb.",
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TY - JOUR

T1 - Gestational age and neonatal brain microstructure in term born infants

T2 - A birth cohort study

AU - Broekman, Birit F P

AU - Wang, Changqing

AU - Li, Yue

AU - Rifkin-Graboi, Anne

AU - Saw, Seang Mei

AU - Chong, Yap Seng

AU - Kwek, Kenneth

AU - Gluckman, Peter D.

AU - Fortier, Marielle V.

AU - Meaney, Michael J.

AU - Qiu, Anqi

AU - Sheppard, Allan

AU - Chinnadurai, Amutha

AU - Ferguson-Smith, Anne

AU - Goh, Anne Eng Neo

AU - Biswas, Arijit

AU - Chia, Audrey

AU - Broekman, Birit

AU - Shuter, Borys

AU - Cai, Shirong

AU - Huak, Chan Yiong

AU - Ngo, Cheryl

AU - Chin, Chiang Wen

AU - Chng, Chai Kiat

AU - Chong, Shang Chee

AU - Henry, Christiani Jeyakumar

AU - Chua, Mei Chien

AU - Chee, Cornelia Yin Ing

AU - Goh, Yam Thiam Daniel

AU - Bier, Dennis

AU - Ding, Chun Ming

AU - Fok, Doris

AU - Finkelstein, Eric Andrew

AU - Yap, Fabian Kok Peng

AU - Yeo, George Seow Heong

AU - Han, Wee Meng

AU - Chen, Helen

AU - Verkooijen, Helena Marieke

AU - Van Bever, Hugo P S

AU - Inskip, Hazel

AU - Magiati, Iliana

AU - Wong, Inez Bik Yun

AU - Kapur, Jeevesh

AU - Richmond, Jenny L.

AU - Chan, Jerry Kok Yen

AU - Holbrook, Johanna

AU - Gooley, Joshua J.

AU - Godfrey, Keith M.

AU - Niduvaje, Krishnamoorthy

AU - Lee, Bee Wah

AU - Lee, Yung Seng

AU - Singh, Leher

AU - Lim, Sok Bee

AU - Daniel, Lourdes Mary

AU - Loh, Seong Feei

AU - Low, Yen Ling

AU - Shek, Pei Chi Lynette

AU - Fortier, Marielle

AU - Hanson, Mark

AU - Chong, Mary Foong Fong

AU - Heymann, Michael H.

AU - Meaney, Michael

AU - Hartman, Mikael

AU - Tint, Mya Thway

AU - Morton, Susan

AU - Pang, Wei Wei

AU - Gluckman, Peter

AU - Agarwal, Pratibha

AU - Quah, Boon Long

AU - Van Dam, Rob M.

AU - Stringer, David

AU - Rebello, Salome Antonette

AU - So, Wing Chee

AU - Chee, So Wing

AU - Soh Shu, E.

AU - Hsu, Chin Ying

AU - Su, Lin Lin

AU - Tang, Jenny

AU - Tan, Kok Hian

AU - Tan, Soek Hui

AU - Teoh, Oon Hoe

AU - Yin, Terry Tong Yoke

AU - Walczyk, Thomas

AU - Rajadurai, Victor Samuel

AU - Stunkel, Walter

AU - Venkatesh, Sudhakar K

AU - Cheang, Wong Peng

AU - Wong, P. C.

AU - Venkatesh, Sudhakar K.

PY - 2014/12/23

Y1 - 2014/12/23

N2 - Objective: Understanding healthy brain development in utero is crucial in order to detect abnormal developmental trajectories due to developmental disorders. However, in most studies neuroimaging was done after a significant postnatal period, and in those studies that performed neuroimaging on fetuses, the quality of data has been affected due to complications of scanning during pregnancy. To understand healthy brain development between 37-41 weeks of gestational age, our study assessed the in utero growth of the brain in healthy term born babies with DTI scanning soon after birth.Methods: A cohort of 93 infants recruited from maternity hospitals in Singapore underwent diffusion tensor imaging between 5 to 17 days after birth. We did a cross-sectional examination of white matter microstructure of the brain among healthy term infants as a function of gestational age via voxel-based analysis on fractional anisotropy.Results: Greater gestational age at birth in term infants was associated with larger fractional anisotropy values in early developing brain regions, when corrected for age at scan. Specifically, it was associated with a cluster located at the corpus callosum (corrected p<0.001), as well as another cluster spanning areas of the anterior corona radiata, anterior limb of internal capsule, and external capsule (corrected p<0.001).Conclusions: Our findings show variation in brain maturation associated with gestational age amongst 'term' infants, with increased brain maturation when born with a relatively higher gestational age in comparison to those infants born with a relatively younger gestational age. Future studies should explore if these differences in brain maturation between 37 and 41 weeks of gestational age will persist over time due to development outside the womb.

AB - Objective: Understanding healthy brain development in utero is crucial in order to detect abnormal developmental trajectories due to developmental disorders. However, in most studies neuroimaging was done after a significant postnatal period, and in those studies that performed neuroimaging on fetuses, the quality of data has been affected due to complications of scanning during pregnancy. To understand healthy brain development between 37-41 weeks of gestational age, our study assessed the in utero growth of the brain in healthy term born babies with DTI scanning soon after birth.Methods: A cohort of 93 infants recruited from maternity hospitals in Singapore underwent diffusion tensor imaging between 5 to 17 days after birth. We did a cross-sectional examination of white matter microstructure of the brain among healthy term infants as a function of gestational age via voxel-based analysis on fractional anisotropy.Results: Greater gestational age at birth in term infants was associated with larger fractional anisotropy values in early developing brain regions, when corrected for age at scan. Specifically, it was associated with a cluster located at the corpus callosum (corrected p<0.001), as well as another cluster spanning areas of the anterior corona radiata, anterior limb of internal capsule, and external capsule (corrected p<0.001).Conclusions: Our findings show variation in brain maturation associated with gestational age amongst 'term' infants, with increased brain maturation when born with a relatively higher gestational age in comparison to those infants born with a relatively younger gestational age. Future studies should explore if these differences in brain maturation between 37 and 41 weeks of gestational age will persist over time due to development outside the womb.

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DO - 10.1371/journal.pone.0115229

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VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e115229

ER -