Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

Hanna K. Sanoff, Lindsay A. Renfro, Pradeep Poonnen, Pratibha Ambadwar, Daniel J. Sargent, Richard M. Goldberg, Howard McLeod

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. Results: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). Conclusion: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.

Original languageEnglish (US)
Article numbere94727
JournalPloS one
Volume9
Issue number4
DOIs
StatePublished - Apr 11 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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