Germline miRNA DNA variants and the risk of colorectal cancer by subtype

Noralane Morey Lindor, Melissa C. Larson, Melissa S. DeRycke, Shannon K. McDonnell, Saurabh Baheti, Zachary C. Fogarty, Aung Ko Win, John D. Potter, Daniel D. Buchanan, Mark Clendenning, Polly A. Newcomb, Graham Casey, Steven Gallinger, Loïc Le Marchand, John L. Hopper, Mark A. Jenkins, Ellen L Goode, Stephen N Thibodeau

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) regulate up to one-third of all protein-coding genes including genes relevant to cancer. Variants within miRNAs have been reported to be associated with prognosis, survival, response to chemotherapy across cancer types, in vitro parameters of cell growth, and altered risks for development of cancer. Five miRNA variants have been reported to be associated with risk for development of colorectal cancer (CRC). In this study, we evaluated germline genetic variation in 1,123 miRNAs in 899 individuals with CRCs categorized by clinical subtypes and in 204 controls. The role of common miRNA variation in CRC was investigated using single variant and miRNA-level association tests. Twenty-nine miRNAs and 30 variants exhibited some marginal association with CRC in at least one subtype of CRC. Previously reported associations were not confirmed (n = 4) or could not be evaluated (n = 1). The variants noted for the CRCs with deficient mismatch repair showed little overlap with the variants noted for CRCs with proficient mismatch repair, consistent with our evolving understanding of the distinct biology underlying these two groups.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalGenes Chromosomes and Cancer
Volume56
Issue number3
DOIs
StatePublished - Mar 1 2017

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MicroRNAs
Colorectal Neoplasms
DNA
DNA Mismatch Repair
Neoplasms
Drug Therapy
Growth
Genes
Proteins

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Germline miRNA DNA variants and the risk of colorectal cancer by subtype. / Lindor, Noralane Morey; Larson, Melissa C.; DeRycke, Melissa S.; McDonnell, Shannon K.; Baheti, Saurabh; Fogarty, Zachary C.; Win, Aung Ko; Potter, John D.; Buchanan, Daniel D.; Clendenning, Mark; Newcomb, Polly A.; Casey, Graham; Gallinger, Steven; Le Marchand, Loïc; Hopper, John L.; Jenkins, Mark A.; Goode, Ellen L; Thibodeau, Stephen N.

In: Genes Chromosomes and Cancer, Vol. 56, No. 3, 01.03.2017, p. 177-184.

Research output: Contribution to journalArticle

Lindor, NM, Larson, MC, DeRycke, MS, McDonnell, SK, Baheti, S, Fogarty, ZC, Win, AK, Potter, JD, Buchanan, DD, Clendenning, M, Newcomb, PA, Casey, G, Gallinger, S, Le Marchand, L, Hopper, JL, Jenkins, MA, Goode, EL & Thibodeau, SN 2017, 'Germline miRNA DNA variants and the risk of colorectal cancer by subtype', Genes Chromosomes and Cancer, vol. 56, no. 3, pp. 177-184. https://doi.org/10.1002/gcc.22420
Lindor NM, Larson MC, DeRycke MS, McDonnell SK, Baheti S, Fogarty ZC et al. Germline miRNA DNA variants and the risk of colorectal cancer by subtype. Genes Chromosomes and Cancer. 2017 Mar 1;56(3):177-184. https://doi.org/10.1002/gcc.22420
Lindor, Noralane Morey ; Larson, Melissa C. ; DeRycke, Melissa S. ; McDonnell, Shannon K. ; Baheti, Saurabh ; Fogarty, Zachary C. ; Win, Aung Ko ; Potter, John D. ; Buchanan, Daniel D. ; Clendenning, Mark ; Newcomb, Polly A. ; Casey, Graham ; Gallinger, Steven ; Le Marchand, Loïc ; Hopper, John L. ; Jenkins, Mark A. ; Goode, Ellen L ; Thibodeau, Stephen N. / Germline miRNA DNA variants and the risk of colorectal cancer by subtype. In: Genes Chromosomes and Cancer. 2017 ; Vol. 56, No. 3. pp. 177-184.
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