Geriatric Assessment in Older Adults with Multiple Myeloma

Tanya M. Wildes, Sascha A. Tuchman, Heidi D. Klepin, Joseph Mikhael, Kathryn Trinkaus, Keith Stockerl-Goldstein, Ravi Vij, Graham Colditz

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

BACKGROUND/OBJECTIVES: The incidence of myeloma in older adults is increasing, yet little is known about geriatric impairments in these patients. We aimed to examine the prevalence of geriatric impairments in older adults with myeloma and the association between geriatric assessment and autologous stem cell transplant eligibility. DESIGN: Prospective cohort study. SETTING: Two academic medical centers. PARTICIPANTS: A total of 40 adults 65 years and older with newly diagnosed myeloma were enrolled. MEASUREMENT: Participants completed a primarily self-administered geriatric assessment, including measures of functional status, comorbidities, polypharmacy, psychosocial status, social support, quality of life, cognition, and physical performance. Outcomes were autologous stem cell transplant eligibility and receipt. RESULTS: Forty patients enrolled; their mean age was 71 years. Geriatric impairments were common: 62% reported dependence in one or more instrumental activities of daily living (IADL), 76.9% had polypharmacy (four or more medications), and 47.5% had one or more comorbidities. Median time on the Timed Up and Go was 13.3 ± 4.9 seconds. Those considered candidates for autologous stem cell transplant (N = 26) were younger, with fewer comorbidities, better performance status, and faster performance on the Timed Up and Go test. Factors independently associated with receiving autologous stem cell transplant (N = 21) included age and IADL dependence. CONCLUSION: Impairments in geriatric domains are common in this population, even among those considered to have a good performance status. Geriatric assessment domains are associated with both transplant eligibility and receipt. J Am Geriatr Soc 67:987–991, 2019.

Original languageEnglish (US)
Pages (from-to)987-991
Number of pages5
JournalJournal of the American Geriatrics Society
Volume67
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • aged
  • elderly persons
  • geriatric assessment
  • hematopoietic stem cell transplantation
  • multiple myeloma

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Geriatric Assessment in Older Adults with Multiple Myeloma'. Together they form a unique fingerprint.

  • Cite this

    Wildes, T. M., Tuchman, S. A., Klepin, H. D., Mikhael, J., Trinkaus, K., Stockerl-Goldstein, K., Vij, R., & Colditz, G. (2019). Geriatric Assessment in Older Adults with Multiple Myeloma. Journal of the American Geriatrics Society, 67(5), 987-991. https://doi.org/10.1111/jgs.15715