GERD-related cough: Pathophysiology and diagnostic approach

Jaclyn A. Smith, Rayid Abdulqawi, Lesley A. Houghton

Research output: Contribution to journalReview article

15 Scopus citations


Chronic cough is a common problem resulting in significant impairment of quality of life. Along with cough variant asthma and nasal disease, gastroesophageal reflux is considered one of three main causes of cough. Despite this, acid suppression therapy is often far from effective. This review aims to explore whether reflux can lead to cough, the circumstances in which this is most likely to occur, and the potential mechanisms linking these processes. Particular mechanisms to be explored include laryngopharyngeal reflux, microaspiration, and neuronal cross-organ sensitization. Finally, diagnostic approaches are considered.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalCurrent gastroenterology reports
Issue number3
StatePublished - Jun 1 2011


  • Chronic cough
  • Cough sounds
  • Cross-organ sensitization
  • Gastroesophageal reflux
  • Laryngopharyngeal reflux
  • Microaspiration

ASJC Scopus subject areas

  • Gastroenterology

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