GERD-related cough

Pathophysiology and diagnostic approach

Jaclyn A. Smith, Rayid Abdulqawi, Lesley A. Houghton

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chronic cough is a common problem resulting in significant impairment of quality of life. Along with cough variant asthma and nasal disease, gastroesophageal reflux is considered one of three main causes of cough. Despite this, acid suppression therapy is often far from effective. This review aims to explore whether reflux can lead to cough, the circumstances in which this is most likely to occur, and the potential mechanisms linking these processes. Particular mechanisms to be explored include laryngopharyngeal reflux, microaspiration, and neuronal cross-organ sensitization. Finally, diagnostic approaches are considered.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalCurrent Gastroenterology Reports
Volume13
Issue number3
DOIs
StatePublished - Jun 2011

Fingerprint

Gastroesophageal Reflux
Cough
Laryngopharyngeal Reflux
Nose Diseases
Asthma
Quality of Life
Acids
Therapeutics

Keywords

  • Chronic cough
  • Cough sounds
  • Cross-organ sensitization
  • Gastroesophageal reflux
  • Laryngopharyngeal reflux
  • Microaspiration

ASJC Scopus subject areas

  • Gastroenterology

Cite this

GERD-related cough : Pathophysiology and diagnostic approach. / Smith, Jaclyn A.; Abdulqawi, Rayid; Houghton, Lesley A.

In: Current Gastroenterology Reports, Vol. 13, No. 3, 06.2011, p. 247-256.

Research output: Contribution to journalArticle

Smith, Jaclyn A. ; Abdulqawi, Rayid ; Houghton, Lesley A. / GERD-related cough : Pathophysiology and diagnostic approach. In: Current Gastroenterology Reports. 2011 ; Vol. 13, No. 3. pp. 247-256.
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