Geometric modeling of space optimal unit cell based tissue engineering scaffolds

Srinivasan Rajagopalan, Lichun Lu, Michael J Yaszemski, M. D Richard Robb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Tissue engineering involves regenerating damaged or malfunctioning organs using cells, biomolecules, and synthetic or natural scaffolds. Based on their intended roles, scaffolds can be injected as space-fillers or be preformed and implanted to provide mechanical support. Preformed scaffolds are biomimetic "trellis-like" structures which, on implantation and integration, act as tissue/organ surrogates. Customized, computer controlled, and reproducible preformed scaffolds can be fabricated using Computer Aided Design (CAD) techniques and rapid prototyping devices. A curved, monolithic construct with minimal surface area constitutes an efficient substrate geometry that promotes cell attachment, migration and proliferation. However, current CAD approaches do not provide such a biomorphic construct. We address this critical issue by presenting one of the very first physical realizations of minimal surfaces towards the construction of efficient unit-cell based tissue engineering scaffolds. Mask programmability, and optimal packing density of triply periodic minimal surfaces are used to construct the optimal pore geometry. Budgeted polygonization, and progressive minimal surface refinement facilitate the machinability of these surfaces. The efficient stress distributions, as deduced from the Finite Element simulations, favor the use of these scaffolds for orthopedic applications.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsR.L. Galloway, Jr., K.R. Cleary
Pages636-647
Number of pages12
Volume5744
EditionII
DOIs
StatePublished - 2005
EventMedical Imaging 2005 - Visualization, Image-Guided Procedures, and Display - San Diego, CA, United States
Duration: Feb 13 2005Feb 15 2005

Other

OtherMedical Imaging 2005 - Visualization, Image-Guided Procedures, and Display
CountryUnited States
CitySan Diego, CA
Period2/13/052/15/05

Fingerprint

Scaffolds (biology)
Tissue engineering
Scaffolds
Computer aided design
Machinability
Geometry
Orthopedics
Biomimetics
Rapid prototyping
Biomolecules
Fillers
Stress concentration
Masks
Tissue
Substrates

Keywords

  • Computer Aided Design (CAD)
  • Minimal Surfaces
  • Scaffolds
  • Solid Free Form Fabrication (SFF)
  • Tissue Engineering
  • Triply Periodic Minimal Surface (TPMS)

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Rajagopalan, S., Lu, L., Yaszemski, M. J., & Robb, M. D. R. (2005). Geometric modeling of space optimal unit cell based tissue engineering scaffolds. In R. L. Galloway, Jr., & K. R. Cleary (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (II ed., Vol. 5744, pp. 636-647). [70] https://doi.org/10.1117/12.594602

Geometric modeling of space optimal unit cell based tissue engineering scaffolds. / Rajagopalan, Srinivasan; Lu, Lichun; Yaszemski, Michael J; Robb, M. D Richard.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / R.L. Galloway, Jr.; K.R. Cleary. Vol. 5744 II. ed. 2005. p. 636-647 70.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rajagopalan, S, Lu, L, Yaszemski, MJ & Robb, MDR 2005, Geometric modeling of space optimal unit cell based tissue engineering scaffolds. in RL Galloway, Jr. & KR Cleary (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. II edn, vol. 5744, 70, pp. 636-647, Medical Imaging 2005 - Visualization, Image-Guided Procedures, and Display, San Diego, CA, United States, 2/13/05. https://doi.org/10.1117/12.594602
Rajagopalan S, Lu L, Yaszemski MJ, Robb MDR. Geometric modeling of space optimal unit cell based tissue engineering scaffolds. In Galloway, Jr. RL, Cleary KR, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. II ed. Vol. 5744. 2005. p. 636-647. 70 https://doi.org/10.1117/12.594602
Rajagopalan, Srinivasan ; Lu, Lichun ; Yaszemski, Michael J ; Robb, M. D Richard. / Geometric modeling of space optimal unit cell based tissue engineering scaffolds. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / R.L. Galloway, Jr. ; K.R. Cleary. Vol. 5744 II. ed. 2005. pp. 636-647
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