Geobiology reveals how human kidney stones dissolve in vivo

Mayandi Sivaguru, Jessica J. Saw, James C. Williams, John C Lieske, Amy E. Krambeck, Michael F Romero, Nicholas D Chia, Andrew L. Schwaderer, Reinaldo E. Alcalde, William J. Bruce, Derek E. Wildman, Glenn A. Fried, Charles J. Werth, Richard J. Reeder, Peter M. Yau, Robert A. Sanford, Bruce W. Fouke

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

More than 10% of the global human population is now afflicted with kidney stones, which are commonly associated with other significant health problems including diabetes, hypertension and obesity. Nearly 70% of these stones are primarily composed of calcium oxalate, a mineral previously assumed to be effectively insoluble within the kidney. This has limited currently available treatment options to painful passage and/or invasive surgical procedures. We analyze kidney stone thin sections with a combination of optical techniques, which include bright field, polarization, confocal and super-resolution nanometer-scale auto-fluorescence microscopy. Here we demonstrate using interdisciplinary geology and biology (geobiology) approaches that calcium oxalate stones undergo multiple events of dissolution as they crystallize and grow within the kidney. These observations open a fundamentally new paradigm for clinical approaches that include in vivo stone dissolution and identify high-frequency layering of organic matter and minerals as a template for biomineralization in natural and engineered settings.

Original languageEnglish (US)
Article number13731
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Calcium Oxalate
Kidney Calculi
Minerals
Geology
Kidney
Fluorescence Microscopy
Obesity
Hypertension
Health
Population

ASJC Scopus subject areas

  • General

Cite this

Sivaguru, M., Saw, J. J., Williams, J. C., Lieske, J. C., Krambeck, A. E., Romero, M. F., ... Fouke, B. W. (2018). Geobiology reveals how human kidney stones dissolve in vivo. Scientific Reports, 8(1), [13731]. https://doi.org/10.1038/s41598-018-31890-9

Geobiology reveals how human kidney stones dissolve in vivo. / Sivaguru, Mayandi; Saw, Jessica J.; Williams, James C.; Lieske, John C; Krambeck, Amy E.; Romero, Michael F; Chia, Nicholas D; Schwaderer, Andrew L.; Alcalde, Reinaldo E.; Bruce, William J.; Wildman, Derek E.; Fried, Glenn A.; Werth, Charles J.; Reeder, Richard J.; Yau, Peter M.; Sanford, Robert A.; Fouke, Bruce W.

In: Scientific Reports, Vol. 8, No. 1, 13731, 01.12.2018.

Research output: Contribution to journalArticle

Sivaguru, M, Saw, JJ, Williams, JC, Lieske, JC, Krambeck, AE, Romero, MF, Chia, ND, Schwaderer, AL, Alcalde, RE, Bruce, WJ, Wildman, DE, Fried, GA, Werth, CJ, Reeder, RJ, Yau, PM, Sanford, RA & Fouke, BW 2018, 'Geobiology reveals how human kidney stones dissolve in vivo', Scientific Reports, vol. 8, no. 1, 13731. https://doi.org/10.1038/s41598-018-31890-9
Sivaguru, Mayandi ; Saw, Jessica J. ; Williams, James C. ; Lieske, John C ; Krambeck, Amy E. ; Romero, Michael F ; Chia, Nicholas D ; Schwaderer, Andrew L. ; Alcalde, Reinaldo E. ; Bruce, William J. ; Wildman, Derek E. ; Fried, Glenn A. ; Werth, Charles J. ; Reeder, Richard J. ; Yau, Peter M. ; Sanford, Robert A. ; Fouke, Bruce W. / Geobiology reveals how human kidney stones dissolve in vivo. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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