Genomics and complex liver disease: Challenges and opportunities

Brian D. Juran, Konstantinos N Lazaridis

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The concept of genetic susceptibility in the contribution to human disease is not new. What is new is the emerging ability of the field of genomics to detect, assess, and interpret genetic variation in the study of susceptibility to development of disease. Deciphering the human genome sequence and the publication of the human haplotype map are key elements of this effort. However, we are only beginning to understand the contribution of genetic predisposition to complex liver disease through its interaction with environmental risk factors. In the coming decade, we anticipate the development of human studies to better dissect the genotype/phenotype relationship of complex liver diseases. This endeavor will require large, well-phenotyped patient populations of each disease of interest and proper study designs aimed at answering important questions of hepatic disease prognosis, pathogenesis, and treatment. Teamwork between patients, physicians, and genomics scientists can ensure that this opportunity leads to important biological discoveries and improved treatment of complex disease.

Original languageEnglish (US)
Pages (from-to)1380-1390
Number of pages11
JournalHepatology
Volume44
Issue number6
DOIs
StatePublished - Dec 2006

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Genomics
Liver Diseases
Genetic Predisposition to Disease
HapMap Project
Aptitude
Human Development
Human Genome
Publications
Genotype
Physicians
Phenotype
Liver
Therapeutics
Population

ASJC Scopus subject areas

  • Hepatology

Cite this

Genomics and complex liver disease : Challenges and opportunities. / Juran, Brian D.; Lazaridis, Konstantinos N.

In: Hepatology, Vol. 44, No. 6, 12.2006, p. 1380-1390.

Research output: Contribution to journalArticle

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