Genomic signatures of cancer: Basis for individualized risk assessment, selective staging and therapy

Frederick L. Baehner, Mark Lee, Michael J. Demeure, Kimberly J. Bussey, Jeffrey A. Kiefer, Michael T. Barrett

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The development of DNA microarray and quantitative real-time polymerase chain reaction technologies has allowed for precise quantitation of RNA expression of hundreds to thousands of genes. These technologies have significantly impacted the study and understanding of cancer in terms of its molecular and genetic characteristics. In this review article, breast cancer, colon cancer, and adrenal carcinoma have been chosen to illustrate the principle and techniques of genomic profiling and to illustrate how such methods may be used to develop genomic signatures for personalized risk assessment and to individualize patient treatment.

Original languageEnglish (US)
Pages (from-to)563-573
Number of pages11
JournalJournal of Surgical Oncology
Volume103
Issue number6
DOIs
StatePublished - May 1 2011

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Keywords

  • adrenal cancer
  • biomarkers
  • breast cancer
  • colon cancer
  • gene expression array

ASJC Scopus subject areas

  • Surgery
  • Oncology

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