Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon

William A. Hammond; Jennifer A. Crozier; Raouf E. Nakhleh; Kabir Mody

doi:10.3978/j.issn.2078-6891.2015.090

Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon

William A. Hammond, Jennifer A. Crozier, Raouf E. Nakhleh, Kabir Mody

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.

Original language	English (US)
Pages (from-to)	E22-E24
Journal	Journal of Gastrointestinal Oncology
Volume	7
Issue number	2
DOIs	https://doi.org/10.3978/j.issn.2078-6891.2015.090
State	Published - Apr 1 2016

Keywords

Colon cancer
Genomic profiling
Neuroendocrine carcinoma

ASJC Scopus subject areas

Oncology
Gastroenterology

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10.3978/j.issn.2078-6891.2015.090

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title = "Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon",

abstract = "High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.",

keywords = "Colon cancer, Genomic profiling, Neuroendocrine carcinoma",

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AU - Crozier, Jennifer A.

AU - Nakhleh, Raouf E.

AU - Mody, Kabir

PY - 2016/4/1

Y1 - 2016/4/1

N2 - High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.

AB - High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.

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KW - Genomic profiling

KW - Neuroendocrine carcinoma

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Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon

Abstract

Keywords

ASJC Scopus subject areas

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