Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon

William A. Hammond, Jennifer A. Crozier, Raouf E. Nakhleh, Kabir Mody

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type.

Original languageEnglish (US)
Pages (from-to)E22-E24
JournalJournal of Gastrointestinal Oncology
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Neuroendocrine Carcinoma
Large Cell Carcinoma
Colon
Neoplasms
Mutation
Small Cell Lung Carcinoma
Phosphatidylinositol 3-Kinases
Therapeutics
Survival

Keywords

  • Colon cancer
  • Genomic profiling
  • Neuroendocrine carcinoma

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon. / Hammond, William A.; Crozier, Jennifer A.; Nakhleh, Raouf E.; Mody, Kabir.

In: Journal of Gastrointestinal Oncology, Vol. 7, No. 2, 01.04.2016, p. E22-E24.

Research output: Contribution to journalArticle

Hammond, William A. ; Crozier, Jennifer A. ; Nakhleh, Raouf E. ; Mody, Kabir. / Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon. In: Journal of Gastrointestinal Oncology. 2016 ; Vol. 7, No. 2. pp. E22-E24.
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