TY - JOUR
T1 - Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan
AU - Australian Prostate Cancer BioResource (APCB)
AU - The PRACTICAL Consortium
AU - 23andMe Research Team
AU - Hollis, Ben
AU - Day, Felix R.
AU - Busch, Alexander S.
AU - Thompson, Deborah J.
AU - Soares, Ana Luiza G.
AU - Timmers, Paul R.H.J.
AU - Kwong, Alex
AU - Easton, Doug F.
AU - Joshi, Peter K.
AU - Timpson, Nicholas J.
AU - Eeles, Rosalind A.
AU - Henderson, Brian E.
AU - Haiman, Christopher A.
AU - Kote-Jarai, Zsofia
AU - Schumacher, Fredrick R.
AU - Olama, Ali Amin Al
AU - Benlloch, Sara
AU - Muir, Kenneth
AU - Berndt, Sonja I.
AU - Conti, David V.
AU - Wiklund, Fredrik
AU - Chanock, Stephen
AU - Gapstur, Susan
AU - Stevens, Victoria L.
AU - Tangen, Catherine M.
AU - Batra, Jyotsna
AU - Clements, Judith
AU - Gronberg, Henrik
AU - Pashayan, Nora
AU - Schleutker, Johanna
AU - Albanes, Demetrius
AU - Wolk, Alicja
AU - West, Catharine
AU - Mucci, Lorelei
AU - Cancel-Tassin, Géraldine
AU - Koutros, Stella
AU - Sorensen, Karina Dalsgaard
AU - Grindedal, Eli Marie
AU - Neal, David E.
AU - Hamdy, Freddie C.
AU - Donovan, Jenny L.
AU - Travis, Ruth C.
AU - Hamilton, Robert J.
AU - Ingles, Sue Ann
AU - Rosenstein, Barry S.
AU - Lu, Yong Jie
AU - Giles, Graham G.
AU - Kibel, Adam S.
AU - Vega, Ana
AU - Thibodeau, Stephen N.
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes.
AB - The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes.
UR - http://www.scopus.com/inward/record.url?scp=85082380708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082380708&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-14451-5
DO - 10.1038/s41467-020-14451-5
M3 - Article
C2 - 32210231
AN - SCOPUS:85082380708
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 1536
ER -