Abstract
Objective: To compare genome-wide methylation profiles in maternal leukocyte DNA between normotensive and preeclamptic pregnant women at delivery. Methods: Age, body mass index matched case-control comparison of methylation at 27,578 cytosine- guanine sites in 14,495 genes in maternal leukocyte DNA in women with preeclampsia (PE; n=14) and normotensive controls (n=14). Results: PE was associated with widespread differential methylation favoring hypermethylation. Pathway analysis identified the best matched process as a neuropeptide signaling pathway (p<10-5); best matched disease as eclampsia (p<9.97×10-20). Significantly differentially methylated genes (GRIN2b. GABRA1. PCDHB7, and BEX1) are associated with seizures. Conclusion: Altered maternal leukocyte DNA methylation is associated with PE at delivery, and differential methylation of certain neuronal genes may explain the risk for eclampsia.
Original language | English (US) |
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Pages (from-to) | 257-269 |
Number of pages | 13 |
Journal | Hypertension in Pregnancy |
Volume | 32 |
Issue number | 3 |
DOIs | |
State | Published - Aug 2013 |
Keywords
- DNA methylation
- Epigenetics
- Leukocyte
- Maternal
- Preeclampsia
- Pregnancy
ASJC Scopus subject areas
- Internal Medicine
- Obstetrics and Gynecology