Genome-wide linkage analysis for loci affecting pulse pressure: The Family Blood Pressure Program

Suzette J. Bielinski, Amy I. Lynch, Michael B. Miller, Alan Weder, Richard Cooper, Albert Oberman, Yii Der Ida Chen, Stephen T. Turner, Myriam Fornage, Michael Province, Donna K. Arnett

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Pulse pressure, the difference between systolic and diastolic blood pressure, is an independent risk factor for cardiovascular disease. Increased pulse pressure reflects reduced compliance of arteries and is a marker of atherosclerosis. To locate genes that affect pulse pressure, a genome-wide linkage scan for quantitative trait loci influencing pulse pressure was performed using variance components methods as implemented in sequential oligogenic linkage analysis routines. The analysis sample included 10 798 participants in 3320 families who were recruited as part of the Family Blood Pressure Program and were phenotyped with an oscillometric blood pressure measurement device using a consistent protocol across centers. Pulse pressure was adjusted for the effects of sex, age, age 2, age-by-sex interaction, age 2-by-sex interaction, body mass index, and field center to remove sources of variation other than the genetic effects related to pulse pressure. Significant linkage was observed on chromosome 18 (logarithm of odds [LOD]=3.2) in a combined racial sample, chromosome 20 (LOD=4.4), and 17 (LOD=3.6) in Hispanics, chromosome 21 (LOD=4.3) in whites, chromosome 19 (LOD=3.1) in a combined sample of blacks and whites, and chromosome 7 (logarithm of odds [LOD]=3.1) in blacks from the GenNet Network. Our genome scan shows significant evidence for linkage for pulse pressure in multiple areas of the genome, supporting previous published linkage studies. The identification of these loci for pulse pressure and the apparent congruence with other blood pressure phenotypes provide increased support that these regions contain genes influencing blood pressure phenotypes.

Original languageEnglish (US)
Pages (from-to)1286-1293
Number of pages8
JournalHypertension
Volume46
Issue number6
DOIs
StatePublished - Dec 1 2005

Keywords

  • Blood pressure
  • Genetics
  • Hypertension, genetics

ASJC Scopus subject areas

  • Internal Medicine

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    Bielinski, S. J., Lynch, A. I., Miller, M. B., Weder, A., Cooper, R., Oberman, A., Chen, Y. D. I., Turner, S. T., Fornage, M., Province, M., & Arnett, D. K. (2005). Genome-wide linkage analysis for loci affecting pulse pressure: The Family Blood Pressure Program. Hypertension, 46(6), 1286-1293. https://doi.org/10.116110.1161/01.HYP.0000191706.41980.29