Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations

Sharon L.R. Kardia; Laura S. Rozek; Julia Krushkal; Robert E. Ferrell; Stephen T. Turner; Richard Hutchinson; Andrew Brown; Charles F. Sing; Eric Boerwinkle

doi:10.1016/S0895-7061(02)03249-1

Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations

Sharon L.R. Kardia, Laura S. Rozek, Julia Krushkal, Robert E. Ferrell, Stephen T. Turner, Richard Hutchinson, Andrew Brown, Charles F. Sing, Eric Boerwinkle

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

We report the results of a genome-wide linkage scan for hypertension genes in 450 African American hypertensive sibpairs from Jackson, MS, and 539 non-Hispanic white hypertensive sibpairs from Rochester, MN. In the Jackson samples we identified one LOD score peak > 1.0 on chromosome 1. In the Rochester sample, no genomic region had a LOD score > 1.0. These analyses provide no appreciable evidence of hypertension genes with strong effects independent of other genetic and environmental contexts and suggest that stratified linkage analyses may be required to identify hypertension susceptibility genes in these populations.

Original language	English (US)
Pages (from-to)	154-157
Number of pages	4
Journal	American journal of hypertension
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/S0895-7061(02)03249-1
State	Published - Feb 1 2003

Keywords

Genetics
Hypertension
Linkage

ASJC Scopus subject areas

Internal Medicine

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10.1016/S0895-7061(02)03249-1

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title = "Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations",

abstract = "We report the results of a genome-wide linkage scan for hypertension genes in 450 African American hypertensive sibpairs from Jackson, MS, and 539 non-Hispanic white hypertensive sibpairs from Rochester, MN. In the Jackson samples we identified one LOD score peak > 1.0 on chromosome 1. In the Rochester sample, no genomic region had a LOD score > 1.0. These analyses provide no appreciable evidence of hypertension genes with strong effects independent of other genetic and environmental contexts and suggest that stratified linkage analyses may be required to identify hypertension susceptibility genes in these populations.",

keywords = "Genetics, Hypertension, Linkage",

author = "Kardia, {Sharon L.R.} and Rozek, {Laura S.} and Julia Krushkal and Ferrell, {Robert E.} and Turner, {Stephen T.} and Richard Hutchinson and Andrew Brown and Sing, {Charles F.} and Eric Boerwinkle",

note = "Funding Information: The GENOA Network of the NHLBI FBPP is supported by HL54464 and HL54457. LSR was supported by T32 HG00040 from NCHGR. ",

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T1 - Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations

AU - Kardia, Sharon L.R.

AU - Rozek, Laura S.

AU - Krushkal, Julia

AU - Ferrell, Robert E.

AU - Turner, Stephen T.

AU - Hutchinson, Richard

AU - Brown, Andrew

AU - Sing, Charles F.

AU - Boerwinkle, Eric

N1 - Funding Information: The GENOA Network of the NHLBI FBPP is supported by HL54464 and HL54457. LSR was supported by T32 HG00040 from NCHGR.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - We report the results of a genome-wide linkage scan for hypertension genes in 450 African American hypertensive sibpairs from Jackson, MS, and 539 non-Hispanic white hypertensive sibpairs from Rochester, MN. In the Jackson samples we identified one LOD score peak > 1.0 on chromosome 1. In the Rochester sample, no genomic region had a LOD score > 1.0. These analyses provide no appreciable evidence of hypertension genes with strong effects independent of other genetic and environmental contexts and suggest that stratified linkage analyses may be required to identify hypertension susceptibility genes in these populations.

AB - We report the results of a genome-wide linkage scan for hypertension genes in 450 African American hypertensive sibpairs from Jackson, MS, and 539 non-Hispanic white hypertensive sibpairs from Rochester, MN. In the Jackson samples we identified one LOD score peak > 1.0 on chromosome 1. In the Rochester sample, no genomic region had a LOD score > 1.0. These analyses provide no appreciable evidence of hypertension genes with strong effects independent of other genetic and environmental contexts and suggest that stratified linkage analyses may be required to identify hypertension susceptibility genes in these populations.

KW - Genetics

KW - Hypertension

KW - Linkage

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JO - American journal of hypertension

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Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations

Abstract

Keywords

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