Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer

Jane C. Figueiredo, Li Hsu, Carolyn M. Hutter, Yi Lin, Peter T. Campbell, John A. Baron, Sonja I. Berndt, Shuo Jiao, Graham Casey, Barbara Fortini, Andrew T. Chan, Michelle Cotterchio, Mathieu Lemire, Steven Gallinger, Tabitha A. Harrison, Loic Le Marchand, Polly A. Newcomb, Martha L. Slattery, Bette J. Caan, Christopher S. CarlsonBrent W. Zanke, Stephanie A. Rosse, Hermann Brenner, Edward L. Giovannucci, Kana Wu, Jenny Chang-Claude, Stephen J. Chanock, Keith R. Curtis, David Duggan, Jian Gong, Robert W. Haile, Richard B. Hayes, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Laurence N. Kolonel, Conghui Qu, Anja Rudolph, Robert E. Schoen, Fredrick R. Schumacher, Daniela Seminara, Deanna L. Stelling, Stephen N Thibodeau, Mark Thornquist, Greg S. Warnick, Brian E. Henderson, Cornelia M. Ulrich, W. James Gauderman, John D. Potter, Emily White, Ulrike Peters

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk of colorectal cancer. We tested interactions between these dietary factors and approximately 2.7 million genetic variants for colorectal cancer risk among 9,287 cases and 9,117 controls from ten studies. We used logistic regression to investigate multiplicative gene-diet interactions, as well as our recently developed Cocktail method that involves a screening step based on marginal associations and gene-diet correlations and a testing step for multiplicative interactions, while correcting for multiple testing using weighted hypothesis testing. Per quartile increment in the intake of red and processed meat were associated with statistically significant increased risks of colorectal cancer and vegetable, fruit and fiber intake with lower risks. From the case-control analysis, we detected a significant interaction between rs4143094 (10p14/near GATA3) and processed meat consumption (OR = 1.17; p = 8.7E-09), which was consistently observed across studies (p heterogeneity = 0.78). The risk of colorectal cancer associated with processed meat was increased among individuals with the rs4143094-TG and -TT genotypes (OR = 1.20 and OR = 1.39, respectively) and null among those with the GG genotype (OR = 1.03). Our results identify a novel gene-diet interaction with processed meat for colorectal cancer, highlighting that diet may modify the effect of genetic variants on disease risk, which may have important implications for prevention.

Original languageEnglish (US)
Article numbere1004228
JournalPLoS Genetics
Volume10
Issue number4
DOIs
StatePublished - 2014

Fingerprint

gene interaction
colorectal neoplasms
meat
Colorectal Neoplasms
cancer
genome
Genome
diet
Diet
Meat
gene
Genes
vegetable
genotype
Vegetables
fruit
Fruit
Genotype
dietary fiber
hypothesis testing

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)
  • Medicine(all)

Cite this

Figueiredo, J. C., Hsu, L., Hutter, C. M., Lin, Y., Campbell, P. T., Baron, J. A., ... Peters, U. (2014). Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer. PLoS Genetics, 10(4), [e1004228]. https://doi.org/10.1371/journal.pgen.1004228

Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer. / Figueiredo, Jane C.; Hsu, Li; Hutter, Carolyn M.; Lin, Yi; Campbell, Peter T.; Baron, John A.; Berndt, Sonja I.; Jiao, Shuo; Casey, Graham; Fortini, Barbara; Chan, Andrew T.; Cotterchio, Michelle; Lemire, Mathieu; Gallinger, Steven; Harrison, Tabitha A.; Le Marchand, Loic; Newcomb, Polly A.; Slattery, Martha L.; Caan, Bette J.; Carlson, Christopher S.; Zanke, Brent W.; Rosse, Stephanie A.; Brenner, Hermann; Giovannucci, Edward L.; Wu, Kana; Chang-Claude, Jenny; Chanock, Stephen J.; Curtis, Keith R.; Duggan, David; Gong, Jian; Haile, Robert W.; Hayes, Richard B.; Hoffmeister, Michael; Hopper, John L.; Jenkins, Mark A.; Kolonel, Laurence N.; Qu, Conghui; Rudolph, Anja; Schoen, Robert E.; Schumacher, Fredrick R.; Seminara, Daniela; Stelling, Deanna L.; Thibodeau, Stephen N; Thornquist, Mark; Warnick, Greg S.; Henderson, Brian E.; Ulrich, Cornelia M.; Gauderman, W. James; Potter, John D.; White, Emily; Peters, Ulrike.

In: PLoS Genetics, Vol. 10, No. 4, e1004228, 2014.

Research output: Contribution to journalArticle

Figueiredo, JC, Hsu, L, Hutter, CM, Lin, Y, Campbell, PT, Baron, JA, Berndt, SI, Jiao, S, Casey, G, Fortini, B, Chan, AT, Cotterchio, M, Lemire, M, Gallinger, S, Harrison, TA, Le Marchand, L, Newcomb, PA, Slattery, ML, Caan, BJ, Carlson, CS, Zanke, BW, Rosse, SA, Brenner, H, Giovannucci, EL, Wu, K, Chang-Claude, J, Chanock, SJ, Curtis, KR, Duggan, D, Gong, J, Haile, RW, Hayes, RB, Hoffmeister, M, Hopper, JL, Jenkins, MA, Kolonel, LN, Qu, C, Rudolph, A, Schoen, RE, Schumacher, FR, Seminara, D, Stelling, DL, Thibodeau, SN, Thornquist, M, Warnick, GS, Henderson, BE, Ulrich, CM, Gauderman, WJ, Potter, JD, White, E & Peters, U 2014, 'Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer', PLoS Genetics, vol. 10, no. 4, e1004228. https://doi.org/10.1371/journal.pgen.1004228
Figueiredo JC, Hsu L, Hutter CM, Lin Y, Campbell PT, Baron JA et al. Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer. PLoS Genetics. 2014;10(4). e1004228. https://doi.org/10.1371/journal.pgen.1004228
Figueiredo, Jane C. ; Hsu, Li ; Hutter, Carolyn M. ; Lin, Yi ; Campbell, Peter T. ; Baron, John A. ; Berndt, Sonja I. ; Jiao, Shuo ; Casey, Graham ; Fortini, Barbara ; Chan, Andrew T. ; Cotterchio, Michelle ; Lemire, Mathieu ; Gallinger, Steven ; Harrison, Tabitha A. ; Le Marchand, Loic ; Newcomb, Polly A. ; Slattery, Martha L. ; Caan, Bette J. ; Carlson, Christopher S. ; Zanke, Brent W. ; Rosse, Stephanie A. ; Brenner, Hermann ; Giovannucci, Edward L. ; Wu, Kana ; Chang-Claude, Jenny ; Chanock, Stephen J. ; Curtis, Keith R. ; Duggan, David ; Gong, Jian ; Haile, Robert W. ; Hayes, Richard B. ; Hoffmeister, Michael ; Hopper, John L. ; Jenkins, Mark A. ; Kolonel, Laurence N. ; Qu, Conghui ; Rudolph, Anja ; Schoen, Robert E. ; Schumacher, Fredrick R. ; Seminara, Daniela ; Stelling, Deanna L. ; Thibodeau, Stephen N ; Thornquist, Mark ; Warnick, Greg S. ; Henderson, Brian E. ; Ulrich, Cornelia M. ; Gauderman, W. James ; Potter, John D. ; White, Emily ; Peters, Ulrike. / Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer. In: PLoS Genetics. 2014 ; Vol. 10, No. 4.
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AU - Hsu, Li

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AU - Baron, John A.

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AU - Caan, Bette J.

AU - Carlson, Christopher S.

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AU - Rosse, Stephanie A.

AU - Brenner, Hermann

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AU - Schoen, Robert E.

AU - Schumacher, Fredrick R.

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AU - Thibodeau, Stephen N

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