Genome-wide association study of familial lung cancer

Jinyoung Byun, Ann G. Schwartz, Christine Lusk, Angela S. Wenzlaff, Mariza De Andrade, Diptasri Mandal, Colette Gaba, Ping Yang, Ming You, Elena Y. Kupert, Marshall W. Anderson, Younghun Han, Yafang Li, David Qian, Adrienne Stilp, Cathy Laurie, Sarah Nelson, Wenying Zheng, Rayjean J. Hung, Valerie GaborieauJames Mckay, Paul Brennan, Neil E. Caporaso, Maria Teresa Landi, Xifeng Wu, John R. McLaughlin, Yonathan Brhane, Yohan Bossé, Susan M. Pinney, Joan E. Bailey-Wilson, Christopher I. Amos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To identify genetic variation associated with lung cancer risk, we performed a genome-wide association analysis of 685 lung cancer cases that had a family history of two or more first or second degree relatives compared with 744 controls without lung cancer that were genotyped on an Illumina Human OmniExpressExome-8v1 array. To ensure robust results, we further evaluated these findings using data from six additional studies that were assembled through the Transdisciplinary Research on Cancer of the Lung Consortium comprising 1993 familial cases and 33 690 controls. We performed a meta-analysis after imputation of all variants using the 1000 Genomes Project Phase 1 (version 3 release date September 2013). Analyses were conducted for 9 327 222 SNPs integrating data from the two sources. A novel variant on chromosome 4p15.31 near the LCORL gene and an imputed rare variant intergenic between CDKN2A and IFNA8 on chromosome 9p21.3 were identified at a genome-wide level of significance for squamous cell carcinomas. Additionally, associations of CHRNA3 and CHRNA5 on chromosome 15q25.1 in sporadic lung cancer were confirmed at a genome-wide level of significance in familial lung cancer. Previously identified variants in or near CHRNA2, BRCA2, CYP2A6 for overall lung cancer, TERT, SECISPB2L and RTEL1 for adenocarcinoma and RAD52 and MHC for squamous carcinoma were significantly associated with lung cancer.

Original languageEnglish (US)
Pages (from-to)1135-1140
Number of pages6
JournalCarcinogenesis
Volume39
Issue number9
DOIs
StatePublished - Jan 1 2018

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Genome-Wide Association Study
Lung Neoplasms
Chromosomes
Genome
Squamous Cell Carcinoma
Information Storage and Retrieval
Single Nucleotide Polymorphism
Meta-Analysis
Adenocarcinoma
Research
Genes

ASJC Scopus subject areas

  • Cancer Research

Cite this

Byun, J., Schwartz, A. G., Lusk, C., Wenzlaff, A. S., De Andrade, M., Mandal, D., ... Amos, C. I. (2018). Genome-wide association study of familial lung cancer. Carcinogenesis, 39(9), 1135-1140. https://doi.org/10.1093/carcin/bgy080

Genome-wide association study of familial lung cancer. / Byun, Jinyoung; Schwartz, Ann G.; Lusk, Christine; Wenzlaff, Angela S.; De Andrade, Mariza; Mandal, Diptasri; Gaba, Colette; Yang, Ping; You, Ming; Kupert, Elena Y.; Anderson, Marshall W.; Han, Younghun; Li, Yafang; Qian, David; Stilp, Adrienne; Laurie, Cathy; Nelson, Sarah; Zheng, Wenying; Hung, Rayjean J.; Gaborieau, Valerie; Mckay, James; Brennan, Paul; Caporaso, Neil E.; Landi, Maria Teresa; Wu, Xifeng; McLaughlin, John R.; Brhane, Yonathan; Bossé, Yohan; Pinney, Susan M.; Bailey-Wilson, Joan E.; Amos, Christopher I.

In: Carcinogenesis, Vol. 39, No. 9, 01.01.2018, p. 1135-1140.

Research output: Contribution to journalArticle

Byun, J, Schwartz, AG, Lusk, C, Wenzlaff, AS, De Andrade, M, Mandal, D, Gaba, C, Yang, P, You, M, Kupert, EY, Anderson, MW, Han, Y, Li, Y, Qian, D, Stilp, A, Laurie, C, Nelson, S, Zheng, W, Hung, RJ, Gaborieau, V, Mckay, J, Brennan, P, Caporaso, NE, Landi, MT, Wu, X, McLaughlin, JR, Brhane, Y, Bossé, Y, Pinney, SM, Bailey-Wilson, JE & Amos, CI 2018, 'Genome-wide association study of familial lung cancer', Carcinogenesis, vol. 39, no. 9, pp. 1135-1140. https://doi.org/10.1093/carcin/bgy080
Byun J, Schwartz AG, Lusk C, Wenzlaff AS, De Andrade M, Mandal D et al. Genome-wide association study of familial lung cancer. Carcinogenesis. 2018 Jan 1;39(9):1135-1140. https://doi.org/10.1093/carcin/bgy080
Byun, Jinyoung ; Schwartz, Ann G. ; Lusk, Christine ; Wenzlaff, Angela S. ; De Andrade, Mariza ; Mandal, Diptasri ; Gaba, Colette ; Yang, Ping ; You, Ming ; Kupert, Elena Y. ; Anderson, Marshall W. ; Han, Younghun ; Li, Yafang ; Qian, David ; Stilp, Adrienne ; Laurie, Cathy ; Nelson, Sarah ; Zheng, Wenying ; Hung, Rayjean J. ; Gaborieau, Valerie ; Mckay, James ; Brennan, Paul ; Caporaso, Neil E. ; Landi, Maria Teresa ; Wu, Xifeng ; McLaughlin, John R. ; Brhane, Yonathan ; Bossé, Yohan ; Pinney, Susan M. ; Bailey-Wilson, Joan E. ; Amos, Christopher I. / Genome-wide association study of familial lung cancer. In: Carcinogenesis. 2018 ; Vol. 39, No. 9. pp. 1135-1140.
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AU - Lusk, Christine

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AU - De Andrade, Mariza

AU - Mandal, Diptasri

AU - Gaba, Colette

AU - Yang, Ping

AU - You, Ming

AU - Kupert, Elena Y.

AU - Anderson, Marshall W.

AU - Han, Younghun

AU - Li, Yafang

AU - Qian, David

AU - Stilp, Adrienne

AU - Laurie, Cathy

AU - Nelson, Sarah

AU - Zheng, Wenying

AU - Hung, Rayjean J.

AU - Gaborieau, Valerie

AU - Mckay, James

AU - Brennan, Paul

AU - Caporaso, Neil E.

AU - Landi, Maria Teresa

AU - Wu, Xifeng

AU - McLaughlin, John R.

AU - Brhane, Yonathan

AU - Bossé, Yohan

AU - Pinney, Susan M.

AU - Bailey-Wilson, Joan E.

AU - Amos, Christopher I.

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