Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Fredrick R. Schumacher, Stephanie L. Schmit, Shuo Jiao, Christopher K. Edlund, Hansong Wang, Ben Zhang, Li Hsu, Shu Chen Huang, Christopher P. Fischer, John F. Harju, Gregory E. Idos, Flavio Lejbkowicz, Frank J. Manion, Kevin McDonnell, Caroline E. McNeil, Marilena Melas, Hedy S. Rennert, Wei Shi, Duncan C. Thomas, David J. Van Den BergCarolyn M. Hutter, Aaron K. Aragaki, Katja Butterbach, Bette J. Caan, Christopher S. Carlson, Stephen J. Chanock, Keith R. Curtis, Charles S. Fuchs, Manish Gala, Edward L. Giocannucci, Stephanie M. Gogarten, Richard B. Hayes, Brian Henderson, David J. Hunter, Rebecca D. Jackson, Laurence N. Kolonel, Charles Kooperberg, Sebastian Kury, Andrea Lacroix, Cathy C. Laurie, Cecelia A. Laurie, Mathiew Lemire, David Levine, Jing Ma, Karen W. Makar, Conghui Qu, Darin Taverna, Cornelia M. Ulrich, Kana Wu, Suminori Kono, Dee W. West, Sonja I. Berndt, Stephane Bezieau, Hermann Brenner, Peter T. Campbell, Andrew T. Chan, Jenny Chang-Claude, Gerhard A. Coetzee, David V. Conti, David Duggan, Jane C. Figueiredo, Barbara K. Fortini, Steven J. Gallinger, W. James Gauderman, Graham Giles, Roger Green, Robert Haile, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, Eric Jacobs, Motoki Iwasaki, Sun Ha Jee, Mark Jenkins, Wei Hua Jia, Amit Joshi, Li Li, Noralene M. Lindor, Keitaro Matsuo, Victor Moreno, Bhramar Mukherjee, Polly A. Newcomb, John D. Potter, Leon Raskin, Gad Rennert, Stephanie Rosse, Gianluca Severi, Robert E. Schoen, Daniela Seminara, Xiao Ou Shu, Martha L. Slattery, Shoichiro Tsugane, Emily White, Yong Bing Xiang, Brent W. Zanke, Wei Zheng, Loic Le Marchand, Graham Casey, Stephen B. Gruber, Ulrike Peters

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

Original languageEnglish (US)
Article number7138
JournalNature communications
Volume6
DOIs
StatePublished - Jul 7 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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