Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes

F. W. Miller, W. Chen, T. P. O'Hanlon, R. G. Cooper, J. Vencovsky, L. G. Rider, K. Danko, L. R. Wedderburn, I. E. Lundberg, L. M. Pachman, A. M. Reed, Steven R Ytterberg, L. Padyukov, A. Selva-O'Callaghan, T. R. Radstake, D. A. Isenberg, H. Chinoy, W. E R Ollier, P. Scheet, B. PengA. Lee, J. Byun, J. A. Lamb, P. K. Gregersen, C. I. Amos

Research output: Contribution to journalArticle

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Abstract

Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis, 473 juvenile dermatomyositis, 532 polymyositis and 202 adult dermatomyositis, juvenile dermatomyositis or polymyositis patients with anti-histidyl-tRNA synthetase (anti-Jo-1) autoantibodies, and compared them with 4724 controls. Single-nucleotide polymorphisms showing strong associations (P

Original languageEnglish (US)
Pages (from-to)470-480
Number of pages11
JournalGenes and Immunity
Volume16
Issue number7
DOIs
StatePublished - Oct 1 2015

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Miller, F. W., Chen, W., O'Hanlon, T. P., Cooper, R. G., Vencovsky, J., Rider, L. G., Danko, K., Wedderburn, L. R., Lundberg, I. E., Pachman, L. M., Reed, A. M., Ytterberg, S. R., Padyukov, L., Selva-O'Callaghan, A., Radstake, T. R., Isenberg, D. A., Chinoy, H., Ollier, W. E. R., Scheet, P., ... Amos, C. I. (2015). Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes. Genes and Immunity, 16(7), 470-480. https://doi.org/10.1038/gene.2015.28